| Thickness of the human cerebral cortex is associated with metrics of cerebrovascular health in a normative sample of community dwelling older adults. | |
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MedLine Citation:
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PMID: 21035552 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined how wide ranges in levels of risk factors for cerebrovascular disease are associated with thickness of the human cerebral cortex in 115 individuals ages 43-83 with no cerebrovascular or neurologic history. Cerebrovascular risk factors included blood pressure, cholesterol, body mass index, creatinine, and diabetes-related factors. Variables were submitted into a principal components analysis that confirmed four orthogonal factors (blood pressure, cholesterol, cholesterol/metabolic and glucose). T1-weighted MRI was used to create models of the cortex for calculation of regional cortical thickness. Increasing blood pressure factor scores were associated with numerous regions of reduced thickness. Increasing glucose scores were modestly associated with areas of regionally decreased thickness. Increasing cholesterol scores, in contrast, were associated with thicker cortex across the whole brain. All findings were primarily independent of age. These results provide evidence that normal and moderately abnormal levels of parameters used to assess cerebrovascular health may impact brain structure, even in the absence of cerebrovascular disease. Our data have important implications for the clinical management of vascular health, as well as for what is currently conceptualized as "normal aging" as they suggest that subclinical levels of risk may impact cortical gray matter before a disease process is evident. |
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Authors:
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Elizabeth C Leritz; David H Salat; Victoria J Williams; David M Schnyer; James L Rudolph; Lewis Lipsitz; Bruce Fischl; Regina E McGlinchey; William P Milberg |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-10-28 |
Journal Detail:
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Title: NeuroImage Volume: 54 ISSN: 1095-9572 ISO Abbreviation: Neuroimage Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-12 Completed Date: 2011-05-02 Revised Date: 2012-02-15 |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
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Languages: eng Pagination: 2659-71 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Geriatric Research, Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, MA 02130, USA. bleritz@nmr.mgh.harvard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Aging / blood, pathology* Blood Glucose / physiology* Blood Pressure Body Mass Index* Cerebral Cortex / pathology* Cerebrovascular Disorders / pathology, physiopathology Cholesterol / blood* Creatinine / blood Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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AG02238/AG/NIA NIH HHS; BIRN002//PHS HHS; K01AG24898/AG/NIA NIH HHS; K23 NS062148-01/NS/NINDS NIH HHS; K23 NS062148-02S1/NS/NINDS NIH HHS; K23 NS062148-02S2/NS/NINDS NIH HHS; K23 NS062148-05/NS/NINDS NIH HHS; K23NS062148/NS/NINDS NIH HHS; K23NS06214802S1/NS/NINDS NIH HHS; P01AG004390/AG/NIA NIH HHS; P41-RR14075/RR/NCRR NIH HHS; P60AG08812/AG/NIA NIH HHS; R01EB006758/EB/NIBIB NIH HHS; R01NR010827/NR/NINR NIH HHS; R01NS052585/NS/NINDS NIH HHS; U24 RR021382/RR/NCRR NIH HHS; U54 EB005149/EB/NIBIB NIH HHS; U54 EB005149-07/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 57-88-5/Cholesterol; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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