Document Detail

Thickness of fetal membranes: a possible ultrasound marker for preterm delivery.
MedLine Citation:
PMID:  18663768     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate whether measurement of the thickness of the fetal membranes by high-resolution ultrasound is a useful marker to predict preterm delivery. METHODS: One hundred and fifty-eight women with singleton pregnancies at 18-35 gestational weeks were enrolled consecutively at our referral center for obstetric care and the thickness of their fetal membranes was measured using high-resolution ultrasound equipment. Data were analyzed to determine whether there were significant differences between those delivering at term and those delivering preterm. Receiver-operating characteristics (ROC) curves were used to determine the best cut-off point of membrane thickness for predicting preterm birth. RESULTS: Women who delivered preterm had greater fetal membrane thickness than did those who delivered at term (1.67 +/- 0.27 mm vs. 1.14 +/- 0.30 mm, P < 0.0001). For the best cut-off indicated by ROC curve analysis (1.2 mm), the sensitivity and specificity for predicting preterm birth were 100% (95% CI, 80.3-100) and 69.5% (95% CI, 61.2-77.0), respectively, and positive and negative likelihood ratios were 3.3 and 0.0, respectively. CONCLUSION: Sonographic measurement of fetal membrane thickness could be helpful in the prediction of preterm delivery.
F M Severi; C Bocchi; C Voltolini; L E Borges; P Florio; F Petraglia
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  32     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-04     Completed Date:  2009-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  205-9     Citation Subset:  IM    
Copyright Information:
(c) 2008 ISUOG. Published by John Wiley & Sons, Ltd.
Division of Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy.
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MeSH Terms
Extraembryonic Membranes / physiology,  ultrasonography*
Gestational Age
Infant, Newborn
Infant, Premature
Predictive Value of Tests
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Premature Birth / diagnosis*,  prevention & control
ROC Curve
Ultrasonography, Prenatal / methods*
Young Adult

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