Document Detail

Thickening infant formula with digestible and indigestible carbohydrate: availability of calcium, iron, and zinc in vitro.
MedLine Citation:
PMID:  10776946     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Regurgitation is common in infants and is usually due to gastroesophageal reflux. Often parental reassurance and dietary management by feeding thickened formulas are the only therapeutic steps necessary. Adding fibers may interfere with the absorption of micronutrients. METHODS: A continuous-flow dialysis in vitro method with a preliminary intraluminal digestive phase, modified to simulate the conditions of infants less than 6 months of age and children from 6 months of age on, was used to study the availability of calcium, iron, and zinc from thickened and nonthickened first-and second-age infant formulas. Pooled mature human milk was used as the reference standard. The elemental content of the samples and dialysate fractions of calcium, iron, and zinc after digestion was determined by atomic absorption spectrometry. RESULTS: In human milk, calcium, iron, and zinc were highly available for absorptive processes. Availability of calcium, iron, and zinc from nonthickened first- and second-age infant formulas tends to be significantly better than in the corresponding products thickened with locust bean gum. Thickening infant formulas with pregelatinized rice starch, however, does not affect the availability of calcium, iron, and zinc. CONCLUSIONS: It appears that human milk provides optimal conditions for the availability of calcium, iron, and zinc. Availability of calcium, iron, and zinc seems to lower when infant formulas are thickened with indigestible carbohydrates, whereas it does not by adding digestible carbohydrates.
D Bosscher; M Van Caillie-Bertrand; K Van Dyck; H Robberecht; R Van Cauwenbergh; H Deelstra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  30     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-07-27     Completed Date:  2000-07-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  373-8     Citation Subset:  IM    
University of Antwerp, Department of Pharmaceutical Sciences, Belgium.
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MeSH Terms
Biological Availability
Calcium / analysis,  pharmacokinetics
Dietary Carbohydrates*
Gastroesophageal Reflux / diet therapy*
Infant Food / analysis*
Infant Nutritional Physiological Phenomena*
Infant, Newborn
Iron / analysis,  pharmacokinetics
Micronutrients / analysis*,  metabolism
Milk, Human / chemistry
Reproducibility of Results
Spectrophotometry, Atomic
Zinc / analysis,  pharmacokinetics
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Micronutrients; 7439-89-6/Iron; 7440-66-6/Zinc; 7440-70-2/Calcium

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