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A Thick-Walled Fluid-Solid-Growth Model of Abdominal Aortic Aneurysm Evolution: Application to a Patient-Specific Geometry.
MedLine Citation:
PMID:  25473877     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We propose a model for abdominal aortic aneurysms that considers the wall (solid), the blood (fluid) and the wall growth within a three-dimensional finite element framework. The arterial wall is considered as a thick-walled nonlinearly elastic circular cylindrical tube consisting of two layers corresponding to the media-intima and adventitia, where each layer is treated as a fiber-reinforced material with the fibers corresponding to the collagenous component. The blood is modeled as a Newtonian fluid with constant density and viscosity; no slip and no-flux conditions are applied at the arterial wall. The metabolic activity in the arterial wall is reflected by elastin degradation which is coupled with the level of wall shear stress, while the collagen fiber network is continuously remodeled in the artery such that the collagen fiber strain tends towards a homeostatic strain. The computational framework consists of a structural FE-solver (CMISS), a fluid solver using a finite volume formulation and additional routines which pass the aneurysm geometry to the fluid solver and feeds CMISS with the information on the blood flow conditions. One illustrative patient-specific geometry of an abdominal aortic wall is discretized with hexahedral finite elements and the fluid domain is generated by an unstructured tetrahedral mesh with prism layers lining the boundary. The evolution of wall shear stress and elastin degradation is investigated over a time period of 10 years; the influence of transmurally non-uniform elastin degradation is analyzed. The results show that both the elastin and the collagen strains can become transmurally non-uniform during the aneurysm development and that this model can predict the evolution of tortuosity. The proposed methodology provides a realistic basis to further explore the development of patient-specific aneurysmal disease.
Authors:
Andrii Grytsan; Paul Watton; Gerhard A Holzapfel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-12-1
Journal Detail:
Title:  Journal of biomechanical engineering     Volume:  -     ISSN:  1528-8951     ISO Abbreviation:  J Biomech Eng     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-4     Completed Date:  -     Revised Date:  2014-12-5    
Medline Journal Info:
Nlm Unique ID:  7909584     Medline TA:  J Biomech Eng     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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