Document Detail


Thiazolidinediones and metformin associated with improved survival of diabetic prostate cancer patients.
MedLine Citation:
PMID:  21415239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The association between antidiabetic medications and the prognosis of human prostate cancer has not been explored. This study examined the impact of these drugs on the outcomes of diabetic patients with prostate cancer to provide a basis for diabetes management strategy in these patients.
PATIENTS AND METHODS: Records of consecutive prostate cancer patients with coexisting diabetes mellitus type 2 who were treated at the study institution between 15 July 1999 and 31 December 2008 were reviewed. The survival, cancer pathological grade, stage at the time of diagnosis, and antidiabetic pharmacotherapy of the patients were analyzed.
RESULTS: A total of 233 consecutive cases were analyzed. In Kaplan-Meier analysis, thiazolidinedione (log-rank, P = 0.005) and metformin (log-rank, P = 0.035) usage were significant predictors of improved overall survival, while insulin and insulin secretagogue usage were not significant predictors. Multivariate Cox regression analysis showed that thiazolidinedione {hazard ratio [HR] = 0.454 [95% confidence interval (CI) 0.213-0.965], P = 0.040} and metformin [HR = 0.550 (95% CI 0.315-0.960), P = 0.035] usage remained as significant predictors of favorable survival after controlling for variables including age, race, Gleason grade, and stage.
CONCLUSIONS: Thiazolidinediones and metformin appear to be associated with improved overall survival of diabetic prostate cancer patients. The choice of antidiabetic pharmacotherapy may influence overall survival of these patients.
Authors:
X-X He; S M Tu; M-H Lee; S-C J Yeung
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-03-17
Journal Detail:
Title:  Annals of oncology : official journal of the European Society for Medical Oncology / ESMO     Volume:  22     ISSN:  1569-8041     ISO Abbreviation:  Ann. Oncol.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-22     Completed Date:  2012-03-16     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9007735     Medline TA:  Ann Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2640-5     Citation Subset:  IM    
Affiliation:
Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Diabetes Mellitus, Type 2 / complications,  drug therapy*,  mortality
Humans
Hypoglycemic Agents / therapeutic use*
Kaplan-Meier Estimate
Male
Metformin / therapeutic use*
Middle Aged
Multivariate Analysis
Neoplasm Grading
Proportional Hazards Models
Prostatic Neoplasms / complications,  drug therapy*,  mortality
Statistics, Nonparametric
Thiazolidinediones / therapeutic use*
Grant Support
ID/Acronym/Agency:
CA16672/CA/NCI NIH HHS; R01 CA089266/CA/NCI NIH HHS; R01 CA089266-08/CA/NCI NIH HHS; R01 CA089266-09/CA/NCI NIH HHS; R01CA 089266/CA/NCI NIH HHS; R56 CA089266/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Hypoglycemic Agents; 0/Thiazolidinediones; 657-24-9/Metformin
Comments/Corrections

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