Document Detail


Thiamine, thiamine phosphates, and their metabolizing enzymes in human brain.
MedLine Citation:
PMID:  8522961     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Total thiamine (the sum of thiamine and its phosphate esters) concentrations are two- to fourfold lower in human brain than in the brain of other mammals. There were no differences in the total thiamine content between biopsied and autopsied human brain, except that in the latter, thiamine triphosphate was undetectable. The main thiamine phosphate-metabolizing enzymes could be detected in autopsied brain, and the kinetic parameters were comparable to those reported in other species. Thiamine diphosphate levels were lowest in hippocampus (15 +/- 4 pmol/mg of protein) and highest in mammillary bodies (24 +/- 4 pmol/mg of protein). Maximal levels of thiamine and its phosphate ester were found to be present at birth. In parietal cortex and globus pallidus, mean levels of total thiamine in the oldest age group (77-103 years) were, respectively, 21 and 26% lower than those in the middle age group (40-55 years). Unlike cerebral cortex, the globus pallidus showed a sharp drop in thiamine diphosphate levels during infancy, with concentrations in the oldest group being only approximately 50% of the levels present during the first 4 months of life. These data, consistent with previous observations conducted in blood, suggest a tendency toward decreased thiamine status in older people.
Authors:
L Bettendorff; F Mastrogiacomo; S J Kish; T Grisar
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  66     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-01-24     Completed Date:  1996-01-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  250-8     Citation Subset:  IM    
Affiliation:
Laboratory of Neurochemistry, University of Liège, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Acid Anhydride Hydrolases / metabolism*
Adolescent
Adult
Aged
Aged, 80 and over
Aging / metabolism
Autopsy
Biopsy
Brain / anatomy & histology,  enzymology
Brain Chemistry*
Child
Child, Preschool
Energy Metabolism
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Nerve Tissue Proteins / analysis*,  metabolism
Thiamin Pyrophosphokinase / metabolism*
Thiamin-Triphosphatase / metabolism*
Thiamine / analysis*,  metabolism
Thiamine Monophosphate / analysis,  metabolism
Thiamine Pyrophosphate / analysis,  metabolism
Thiamine Triphosphate / analysis,  metabolism
Grant Support
ID/Acronym/Agency:
26034//PHS HHS
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins; 154-87-0/Thiamine Pyrophosphate; 3475-65-8/Thiamine Triphosphate; 532-40-1/Thiamine Monophosphate; 59-43-8/Thiamine; EC 2.7.6.2/Thiamin Pyrophosphokinase; EC 3.6.-/Acid Anhydride Hydrolases; EC 3.6.1.28/Thiamin-Triphosphatase; EC 3.6.1.6/nucleoside-diphosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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