Document Detail

Thiamine deficiency: a cause of childhood ataxia not to be ignored.
MedLine Citation:
PMID:  15720894     Owner:  NLM     Status:  MEDLINE    
We report four cases of childhood ataxia with and without encephalopathies which were successfully managed with thiamine supplementation and diagnosed in retrospect as being caused by thiamine deficiency. The clinical presentations were similar to those previously reported amongst adolescents and adults who ingested the larvae of Anaphe venata, a local delicacy among the Ijeshas of south-western Nigeria, during the rainy season. This has been called seasonal ataxia syndrome. The cases were of interest because the disorder was not described in children in the previous report, which might indicate a worsening nutritional status in these communities. This report is to alert child health physicians in the developing world to the possibility of a pre-existing thiamine deficiency progressing into ataxic disorders when certain foods are ingested.
T A Ogunlesi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of tropical paediatrics     Volume:  24     ISSN:  0272-4936     ISO Abbreviation:  Ann Trop Paediatr     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-02-21     Completed Date:  2005-05-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8210625     Medline TA:  Ann Trop Paediatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  357-60     Citation Subset:  IM    
Department of Paediatrics, Wesley Guild Hospital, Ilesa, Osun State, Nigeria.
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MeSH Terms
Ataxia / diagnosis,  drug therapy,  etiology*
Cerebellar Ataxia / diagnosis,  drug therapy,  etiology
Child, Preschool
Malaria, Falciparum / complications
Thiamine Deficiency / complications*
Treatment Outcome

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