| Thiamin monophosphate in the CSF of patients with amyotrophic lateral sclerosis. | |
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MedLine Citation:
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PMID: 7103799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Free thiamin and thiamin monophosphate levels were determined by an electrophoretic fluorometric micromethod in plasma and CSF of patients with amyotrophic lateral sclerosis (ALS), alcoholics, and controls. In plasma of patients with ALS as well as in plasma and CSF of alcholics, both thiamin and thiamin monophosphate concentrations were decreased so that the thiamin-thiamin monophosphate (T/TMP) ratio remained unchanged compared with that of controls. In CSF of patients with ALS, however, thiamin monophosphate values decreased much more than thiamin levels, so that the T/TMP ratio was significantly increased. The selective impairment of thiamin monophosphate production by nerve cells is likely to result from the reduction of the activity of thiamin pyrophosphatase, an enzyme synthetized and highly concentratd in the Golgi complex. Thiamin pyrophosphatase is known to diminish in ALS as well as in experimental motor neuronal degeneration or axotomy. Thus, the T/TMP ratio could be taken as an index of the impairment of neuronal protein synthesis in ALS. |
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Authors:
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M Poloni; C Patrini; B Rocchelli; G Rindi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of neurology Volume: 39 ISSN: 0003-9942 ISO Abbreviation: Arch. Neurol. Publication Date: 1982 Aug |
Date Detail:
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Created Date: 1982-09-10 Completed Date: 1982-09-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 507-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Alcoholism / blood, cerebrospinal fluid Amyotrophic Lateral Sclerosis / blood, cerebrospinal fluid* Blood Proteins / biosynthesis Female Humans Male Middle Aged Neurons / metabolism Thiamine / analogs & derivatives*, blood, cerebrospinal fluid*, physiology Thiamine Monophosphate / blood, cerebrospinal fluid*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 532-40-1/Thiamine Monophosphate; 59-43-8/Thiamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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