Document Detail

A thiamin derivative inhibits oxidation of exogenous glucose at rest, but not during exercise.
MedLine Citation:
PMID:  20354340     Owner:  NLM     Status:  MEDLINE    
Thiamin (vitamin B(1)) is known to activate carbohydrate metabolism in part through activation of pyruvate dehydrogenase. The purpose of this study was to investigate the effect of thiamin tetrahydrofurfuryl disulfide (TTFD), a thiamin derivative, on utilization of exogenous glucose by measuring oxidation of (13)C-glucose at rest and during prolonged exercise in mice under normal dietary conditions. Mice orally ingested TTFD (0.1 mg/g BW [body weight]) and (13)C-glucose (0.8 mg/g BW) or (13)C-lactate (0.1 mg/g BW) plus glucose (0.8 mg/g BW) at rest or before endurance running. The average percent of (13)C atoms in total (12)C+(13)C ((13)C atom%) in expired air after ingestion of (13)C-glucose at rest was significantly lower in the TTFD group than in the control group. No significant difference was found in (13)C atom% in expired air after ingestion of (13)C-glucose and prolonged exercise. In addition, no significant effect of TTFD was found in expired (13)C atom% after ingestion of (13)C-lactate plus glucose at rest. TTFD also had no effect on concentrations of muscle or liver glycogen at rest. These results suggest that TTFD, which is a thiamin derivative, decreases oxidation of exogenous glucose at rest, but not during exercise.
Hiroyuki Masuda; Haruka Matsumae; Tsuyoshi Masuda; Hideo Hatta
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  56     ISSN:  1881-7742     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-31     Completed Date:  2010-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  9-12     Citation Subset:  IM    
Department of Sports Sciences, The University of Tokyo, Tokyo, Japan.
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MeSH Terms
Carbon Isotopes
Dietary Sucrose / administration & dosage,  metabolism*
Fursultiamin / analogs & derivatives,  pharmacology*
Glucose / administration & dosage,  metabolism*
Lactic Acid / administration & dosage,  metabolism
Mice, Inbred ICR
Physical Endurance / physiology*
Physical Exertion / physiology*
Rest / physiology*
Reg. No./Substance:
0/Carbon Isotopes; 0/Dietary Sucrose; 50-21-5/Lactic Acid; 50-99-7/Glucose; 804-30-8/Fursultiamin

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