| Theta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region. | |
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MedLine Citation:
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PMID: 22079925 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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It was recently proposed that fast gamma oscillations (60-150 Hz) convey spatial information from the medial entorhinal cortex (EC) to the CA1 region of the hippocampus. However, here we describe 2 functionally distinct oscillations within this frequency range, both coupled to the theta rhythm during active exploration and rapid eye movement sleep: an oscillation with peak activity at ∼80 Hz and a faster oscillation centered at ∼140 Hz. The 2 oscillations are differentially modulated by the phase of theta depending on the CA1 layer; theta-80 Hz coupling is strongest at stratum lacunosum-moleculare, while theta-140 Hz coupling is strongest at stratum oriens-alveus. This laminar profile suggests that the ∼80 Hz oscillation originates from EC inputs to deeper CA1 layers, while the ∼140 Hz oscillation reflects CA1 activity in superficial layers. We further show that the ∼140 Hz oscillation differs from sharp wave-associated ripple oscillations in several key characteristics. Our results demonstrate the existence of novel theta-associated high-frequency oscillations and suggest a redefinition of fast gamma oscillations. |
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Authors:
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Robson Scheffer-Teixeira; Hindiael Belchior; Fábio V Caixeta; Bryan C Souza; Sidarta Ribeiro; Adriano B L Tort |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-10 |
Journal Detail:
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Title: Cerebral cortex (New York, N.Y. : 1991) Volume: - ISSN: 1460-2199 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9110718 Medline TA: Cereb Cortex Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Brain Institute, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte 59056, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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