| Thermotolerance and heat acclimation may share a common mechanism in humans. | |
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MedLine Citation:
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PMID: 21613575 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Thermotolerance and heat acclimation are key adaptation processes that have been hitherto viewed as separate phenomena. Here we show these processes share a common basis, as both are governed by the heat shock response. We evaluated the effects of a heat shock response-inhibitor (QUERCETIN;2000mg/d) on established markers of thermotolerance[gastrointestinal barrier permeability, plasma TNF-α, Il-6, and Il-10 concentrations; leukocyte HSP70 content(HSP70)] and heat acclimation[reduced body temperatures, heart rate, and physiologic strain during exercise/heat stress] in male subjects(n=8) completing a 7-day heat acclimation protocol. These same subjects completed an identical protocol under placebo supplementation(PLACEBO). Gastrointestinal barrier permeability and TNF-α were increased on the 1(st) day of exercise/heat stress in QUERCETIN, no differences in these variables were reported in PLACEBO. Exercise HSP70 responses were increased and plasma cytokines(Il-6, Il-10) were decreased on the 7(th) day of heat acclimation in PLACEBO; with concomitant reductions in exercise body temperatures, heart rate, and physiologic strain. In contrast, gastrointestinal barrier permeability remained elevated, HSP70 was not increased, and Il-6, Il-10, and exercise body temperatures were not reduced on the 7(th) day of heat acclimation in QUERCETIN. While exercise heart rate and physiologic strain were reduced in QUERCETIN, this occurred later in exercise than with PLACEBO. Consistent with the concept that thermotolerance and heat acclimation are related through the heat shock response, repeated exercise/heat stress reduces circulating cytokines and increases cytoprotective HSP70, contributing to reductions in cellular and systemic markers of heat strain. Exercising under a heat shock response-inhibitor prevents both cellular and systemic heat adaptations. |
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Authors:
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Matthew R Kuennen; Trevor L Gillum; Karol Dokladny; Edward J Bedrick; Suzanne M Schneider; Pope L Moseley |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-25 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: - ISSN: 1522-1490 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1West Texas A&M University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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