Document Detail


Thermosetting gels with modulated gelation temperature for ophthalmic use: the rheological and gamma scintigraphic studies.
MedLine Citation:
PMID:  12220839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For ophthalmic drug delivery, Pluronic F127 solutions have a phase transition temperature too low for them to be instilled into the eye at room temperature. Refrigerator storage is usually required to make administration easier, whereas the potential irritation of cold to the sensitive ocular tissues may result in poor topical bioavailability. The purpose of this study is to develop a thermosetting gel with a suitable phase transition temperature by combining Pluronic analogs and to examine the influence of incorporating mucoadhesive polysaccharide, sodium hyaluronate (HA-Na), on the ocular retention of the gel. Dynamic rheological method and single photon emission computing tomography (SPECT) technique were used to ex/in vivo evaluate the thermosetting gels, respectively. An optimized formulation containing 21% F127 and 10% F68 increased the phase transition temperature by 9 degrees C as evaluated by elasticity modulus compared to that of individual 21% F127 solution. Rheological behaviors of the Pluronic solutions showed that the combined Pluronic formulation was free flowing liquid below 25 degrees C and converted to a firm gel under the physiological condition. Furthermore, this formulation possessed the highest viscosity both before and after tear dilution at 35 degrees C. Gamma scintigraphic data demonstrated that the clearance of the thermosetting gel labeled with 99mTc-DTPA was significantly delayed with respect to the phosphate buffered solution, and at least a threefold increase of the corneal residence time was achieved. However, no further improvement in the ocular retention was observed when adding HA-Na into the thermosetting gel due to the substantially decreased gel strength.
Authors:
Gang Wei; Hui Xu; Ping Tian Ding; San Ming Li; Jun Min Zheng
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of controlled release : official journal of the Controlled Release Society     Volume:  83     ISSN:  0168-3659     ISO Abbreviation:  J Control Release     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-10     Completed Date:  2002-12-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8607908     Medline TA:  J Control Release     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  65-74     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science B.V.
Affiliation:
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Delivery Systems / methods*
Gels
Ophthalmic Solutions / administration & dosage*,  chemistry
Poloxamer / administration & dosage*,  analogs & derivatives,  chemistry
Rabbits
Radionuclide Imaging / methods,  statistics & numerical data
Rheology
Temperature
Viscosity
Chemical
Reg. No./Substance:
0/Gels; 0/Ophthalmic Solutions; 106392-12-5/Poloxamer

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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