Document Detail


Thermoresponsive nanogels for prolonged duration local anesthesia.
MedLine Citation:
PMID:  22732383     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nanogels based on poly(N-isopropylacrylamide) are attractive vehicles for prolonged duration local anesthesia because of their tunable size, number of functional groups, thermoresponsiveness and anionic charge. Nerve block durations of up to 9h were achieved using acrylic acid-loaded nanogels loaded with bupivacaine. Increasing the anionic charge density of the nanogels or (for more highly acid-functionalized nanogels) decreasing the nanogel size facilitated longer duration of anesthetic release. Small (<300 nm diameter) nanogels formed dense aggregates upon injection in vivo and induced only mild inflammatory responses, while large (>500 nm diameter) nanogels typically remained as liquid-like residues in vivo and induced more severe inflammatory reactions.
Authors:
Todd Hoare; Stuart Young; Michael W Lawlor; Daniel S Kohane
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-23
Journal Detail:
Title:  Acta biomaterialia     Volume:  8     ISSN:  1878-7568     ISO Abbreviation:  Acta Biomater     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-08-28     Completed Date:  2013-01-07     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  101233144     Medline TA:  Acta Biomater     Country:  England    
Other Details:
Languages:  eng     Pagination:  3596-605     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
3T3 Cells
Anesthesia, Local*
Animals
Bupivacaine / administration & dosage,  pharmacology
Cell Death / drug effects
Cell Line
Cell Survival / drug effects
Injections
Male
Mice
Motor Neurons / drug effects
Nerve Block
Particle Size
Polyethylene Glycols / chemistry*
Polyethyleneimine / chemistry*
Rats
Rats, Sprague-Dawley
Sciatic Nerve / drug effects,  pathology
Sensory Receptor Cells / drug effects
Staining and Labeling
Temperature*
Time Factors
Grant Support
ID/Acronym/Agency:
GM073626/GM/NIGMS NIH HHS; R01 GM073626/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/NanoGel; 0/Polyethylene Glycols; 2180-92-9/Bupivacaine; 9002-98-6/Polyethyleneimine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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