| Thermoregulatory responses of unanesthetized rats exposed to gravitational fields of 1 to 4g. | |
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MedLine Citation:
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PMID: 11965664 Owner: NASA Status: MEDLINE |
Abstract/OtherAbstract:
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Rats exposed to 2g environments (achieved by centrifugation) exhibit a decreased ability to maintain colonic temperature (Tco) when challenged with a 1 hr drop in ambient temperature (Ta). As an extension of this work the present study considers whether the altered ability to maintain Tco is proportional to the magnitude of the acceleration field in the range from 1g-4g, and whether the magnitude of the decreased thermoregulatory ability is related to the onset time of the temperature drop relative to that of the acceleration. Male, Sprague-Dawley rats were instrumented on the experimental day with thermistors for measuring Tco. The unanesthetized rat was then placed in a plexiglas chamber, positioned on a centrifuge 1.37 m in radius, and exposed to 1.5, 2, 2.5, 3, 3.5, or 4g for 5-7 hrs. The exposure to reduced temperature (Ta = approximately 7 degrees C) for 1 hr began 3 hrs after initiation of centrifugation. These experiments indicated that the magnitude of the cold-induced drop in Tco was linearly related to the acceleration field. The effect of a specific stressor (cold) on the thermoregulatory system is therefore a direct function of the gravitational field. |
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Authors:
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J M Horowitz; B A Horwitz |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Life sciences and space research Volume: 16 ISSN: 0075-9422 ISO Abbreviation: Life Sci Space Res Publication Date: 1978 |
Date Detail:
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Created Date: 2002-04-19 Completed Date: 2002-08-09 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 1250331 Medline TA: Life Sci Space Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 77-82 Citation Subset: S |
Affiliation:
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Department of Animal Physiology, University of California, Davis, California 95616, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acceleration Animals Body Temperature* Body Temperature Regulation / physiology* Centrifugation Cold Temperature* Hypergravity / adverse effects* Male Rats Rats, Sprague-Dawley Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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