Document Detail

Thermoregulatory responses of tailed and tailless rats to isoproterenol.
MedLine Citation:
PMID:  7296383     Owner:  NLM     Status:  MEDLINE    
Colonic temperatures were measured in tailed and tailless rats at an ambient temperature (Ta) of 26 degrees C prior to and following administration of isoproterenol, a beta-adrenergic agonist, at doses of 0, 12.5, 25.0, 50.0, and 100.0 There was no significant difference between the colonic temperatures of tailed and tailless rats before drug injection. However, mean colonic temperature of tailless rats increased to a maximal level approximately 0.3 degrees higher than that of tailed rats after injection of 25.0, 50.0, and 100.0 micrograms isoproterenol per kilogram. The duration of the hyperthermic response was 50-60 min longer in tailless than tailed rats after administration of 50 and 100 micrograms isoproterenol per kilogram. The rate of oxygen consumption (heat production) increased by 4.5 in both tailed and tailless rats after administration of 50 micrograms isoproterenol per kilogram, the only dose tested. Mean colonic temperature of tailless rats was significantly higher, by 0.2-0.5 degrees than that of tailed rats during the initial 60 min of exposure to Ta 36 degrees C and during the first 40 min following removal from Ta 40 degrees C to Ta 28 degrees C. These results suggest that the tail of the rat is required for short-term maintenance of colonic temperature during both external and internal heat stresses.
D E Spiers; C C Barney; M J Fregly
Related Documents :
11542643 - Study of physiological effects of weightlessness and artificial gravity in the flight o...
7070233 - Modified metabolic responsiveness to glucagon in cold-acclimated and heat-acclimated rats.
575253 - Ultrastructural changes of the corpora lutea in lh-treated cyclic female rats.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  59     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1982-01-09     Completed Date:  1982-01-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  847-52     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Body Temperature Regulation / drug effects*
Hot Temperature
Isoproterenol / pharmacology*
Oxygen Consumption / drug effects
Rats, Inbred Strains
Tail / blood supply,  physiology*
Time Factors
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Expired air volumes of males and females during cold water immersion.
Next Document:  Antagonism of calcium-induced contraction in potassium-depolarized rabbit detrusor muscle strips by ...