Document Detail


Thermoregulatory responses of tailed and tailless rats to isoproterenol.
MedLine Citation:
PMID:  7296383     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Colonic temperatures were measured in tailed and tailless rats at an ambient temperature (Ta) of 26 degrees C prior to and following administration of isoproterenol, a beta-adrenergic agonist, at doses of 0, 12.5, 25.0, 50.0, and 100.0 micrograms.kg-1. There was no significant difference between the colonic temperatures of tailed and tailless rats before drug injection. However, mean colonic temperature of tailless rats increased to a maximal level approximately 0.3 degrees higher than that of tailed rats after injection of 25.0, 50.0, and 100.0 micrograms isoproterenol per kilogram. The duration of the hyperthermic response was 50-60 min longer in tailless than tailed rats after administration of 50 and 100 micrograms isoproterenol per kilogram. The rate of oxygen consumption (heat production) increased by 4.5 mL.min-1.kg-0.75 in both tailed and tailless rats after administration of 50 micrograms isoproterenol per kilogram, the only dose tested. Mean colonic temperature of tailless rats was significantly higher, by 0.2-0.5 degrees than that of tailed rats during the initial 60 min of exposure to Ta 36 degrees C and during the first 40 min following removal from Ta 40 degrees C to Ta 28 degrees C. These results suggest that the tail of the rat is required for short-term maintenance of colonic temperature during both external and internal heat stresses.
Authors:
D E Spiers; C C Barney; M J Fregly
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  59     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1982-01-09     Completed Date:  1982-01-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  847-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Temperature Regulation / drug effects*
Hot Temperature
Isoproterenol / pharmacology*
Kinetics
Male
Oxygen Consumption / drug effects
Rats
Rats, Inbred Strains
Tail / blood supply,  physiology*
Time Factors
Grant Support
ID/Acronym/Agency:
AM-07164-05/AM/NIADDK NIH HHS; HL 14526-09/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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