| Thermoregulatory and metabolic changes during fever in young and old rats. | |
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MedLine Citation:
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PMID: 12893653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We injected old and young rats with lipopolysaccharide (LPS; 50 microg/kg ip) at two ambient temperatures (Ta; 21 and 31 degrees C). Young rats mounted equivalent fevers at both Tas [peak body temperatures (Tb) of 38.3 and 38.7 degrees C, respectively]. The Tb of old rats was not different from baseline (37.3 degrees C) after LPS at Ta 21 degrees C, whereas, at 31 degrees C, their Tb rose to a mean peak of 38.4 degrees C. We also measured the associated thermoregulatory responses by use of calorimetry. At 21 degrees C, young rats developed a fever by increasing both O2 consumption and heat conservation. Old rats did not become febrile, and O2 consumption fell by 15%. Heat loss was the same in old and young rats. At 31 degrees C, young and old rats developed similar fevers with similar increases in heat production and conservation. Our results suggest that the lack of LPS fever in old rats at 21 degrees C is due mainly to the lowered metabolic rate. |
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Authors:
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Jessica B Buchanan; Elizabeth Peloso; Evelyn Satinoff |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2003-07-31 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 285 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-10-14 Completed Date: 2003-11-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R1165-9 Citation Subset: IM |
Affiliation:
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Dept. of Psychology, Univ. of Delaware, Newark, DE 19716, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Body Temperature Regulation / physiology* Energy Metabolism / physiology* Female Fever / chemically induced, metabolism*, physiopathology* Lipopolysaccharides Male Rats Rats, Long-Evans Temperature |
| Grant Support | |
ID/Acronym/Agency:
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R01-MH-41138/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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