| Thermoregulatory effect of intracerebral injections of neuropeptide Y in rats at different environmental temperatures. | |
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MedLine Citation:
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PMID: 8026718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. In order to characterize the thermoregulatory actions of brain neuropeptide Y (NPY), the effects of intra-third ventricular (I3V) injection of NPY on temperatures of colon (Tco), brown adipose tissue (TBAT) and tail skin (Ts) were observed at ambient temperatures (Ta) of 19 and 8 degrees C. 2. The injection of NPY in a dose of 8 mcg/100 g body wt evoked a fall of Tco by about 2 degrees C in both neutral and cold environments. NPY (4 and 8 mcg/100 g body wt) induced dose-dependent Tco falls in rats at thermoneutral environment. The thermolytic reactions induced by I3V administration of NPY were associated with a fall in TBAT but no changes in Is were observed. 3. The results suggest that NPY may mediate hypothermic response in neutral and cold environments mainly by its effects on the brown adipose tissues in the rat. |
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Authors:
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Z Szreder; T Hori; Y Kaizuka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: General pharmacology Volume: 25 ISSN: 0306-3623 ISO Abbreviation: Gen. Pharmacol. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-08-08 Completed Date: 1994-08-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7602417 Medline TA: Gen Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 85-91 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Medical Academy, Gdańsk, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue, Brown
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metabolism Animals Body Temperature Regulation / drug effects*, physiology Brain / drug effects, physiology Cold Temperature Injections, Intraventricular Male Neuropeptide Y / pharmacology*, physiology Rats Rats, Wistar Rectum / physiology Temperature |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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