Document Detail

Thermoregulation: what role for UCPs in mammals and birds?
MedLine Citation:
PMID:  16283555     Owner:  NLM     Status:  MEDLINE    
Mammals and birds are endotherms and respond to cold exposure by the means of regulatory thermogenesis, either shivering or non-shivering. In this latter case, waste of cell energy as heat can be achieved by uncoupling of mitochondrial respiration. Uncoupling proteins, which belong to the mitochondrial carrier family, are able to transport protons and thus may assume a thermogenic function. The mammalian UCP1 physiological function is now well understood and gives to the brown adipose tissue the capacity for heat generation. But is it really the case for its more recently discovered isoforms UCP2 and UCP3? Additionally, whereas more and more evidence suggests that non-shivering also exists in birds, is the avian UCP also involved in response to cold exposure? In this review, we consider the latest advances in the field of UCP biology and present putative functions for UCP1 homologues.
Julien Mozo; Yalin Emre; Frederic Bouillaud; Daniel Ricquier; Francois Criscuolo
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Bioscience reports     Volume:  25     ISSN:  0144-8463     ISO Abbreviation:  Biosci. Rep.     Publication Date:    2005 Jun-Aug
Date Detail:
Created Date:  2005-11-11     Completed Date:  2006-02-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8102797     Medline TA:  Biosci Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  227-49     Citation Subset:  IM    
Faculté de Médecine Necker-Enfants Malades, CNRS-UPR 9078, 156 rue de Vaugirard, 75730, Paris, Cedex 15, France.
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MeSH Terms
Adipose Tissue, Brown / metabolism
Birds / physiology*
Body Temperature Regulation / physiology*
Carrier Proteins / chemistry,  classification,  genetics,  metabolism*
Cold Temperature
Energy Metabolism / physiology
Hormones / metabolism
Ion Channels
Mammals / physiology*
Membrane Proteins / chemistry,  classification,  genetics,  metabolism*
Mitochondria / metabolism
Mitochondrial Proteins
Obesity / genetics,  metabolism
Protein Isoforms / chemistry,  genetics,  metabolism*
Reactive Oxygen Species / metabolism
Reg. No./Substance:
0/Carrier Proteins; 0/Hormones; 0/Ion Channels; 0/Membrane Proteins; 0/Mitochondrial Proteins; 0/Protein Isoforms; 0/Reactive Oxygen Species; 0/mitochondrial uncoupling protein

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