Document Detail

Thermogenic and metabolic response to amino acid solution in brain-dead patients.
MedLine Citation:
PMID:  19130337     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is a strong correlation between amino acid infusion and increase in energy expenditure and thermogenesis. In this study, the effects of amino acid solutions on thermogenesis and energy expenditure were investigated in intensive care patients who were diagnosed as brain death. METHODS: Twenty-six brain-dead patients were included in the study. The patients received a 4 h infusion of standard amino acid solution. Energy expenditure was measured by indirect calorimetric method. ANOVA and Bonferroni tests were used for statistical analysis. RESULTS: The predicted energy expenditure (PEE) values were higher than the resting energy expenditure (REE) values in 24 patients. The mean REE/PEE value in all patients indicated that there was a 29% decrease in REE when compared to PEE. Body temperature and energy expenditure values were not increased during the parenteral infusion of amino acid solutions. There was no statistically significant difference between mean metabolic measurements and basal values at any time interval during the study period. CONCLUSION: We conclude that the stimulatory effect of amino acid solution on energy expenditure and thermogenesis is abolished in brain-dead patients. This result may indicate a possible central pathway responsible for the increase in energy expenditure and thermogenesis.
Ilkin Cankayali; Kubilay Demirağ; Seden Kocabaş; Ali Reşat Moral
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES     Volume:  15     ISSN:  1306-696X     ISO Abbreviation:  Ulus Travma Acil Cerrahi Derg     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-08     Completed Date:  2009-05-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101274231     Medline TA:  Ulus Travma Acil Cerrahi Derg     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  39-44     Citation Subset:  IM    
Department of Anesthesiology and Intensive Care Unit, Ege University Faculty of Medicine, Izmir, Turkey.
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MeSH Terms
Amino Acids / administration & dosage,  metabolism*,  pharmacology*
Analysis of Variance
Brain Death / metabolism*
Calorimetry, Indirect
Energy Metabolism / drug effects*,  physiology
Infusions, Parenteral
Intensive Care
Oxygen Consumption
Predictive Value of Tests
Thermogenesis / drug effects*,  physiology
Reg. No./Substance:
0/Amino Acids

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