| Thermogenesis and fatty acid composition of brown adipose tissue in rats rendered hyperthyroid and hypothyroid-with special reference to docosahexaenoic acid. | |
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MedLine Citation:
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PMID: 9852344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of hyperthyroidism and hypothyroidism on brown adipose tissue (BAT) thermogenesis and phospholipid fatty acid composition were investigated in rats. Chronic triiodothyronine (T3) treatment (hyperthyroidism) increased the interscapular BAT pad weight, its triacylglycerol content, and its DNA content. It did not affect basal and noradrenaline-stimulated in vitro oxygen consumption of BAT expressed per microg DNA, although it significantly increased the oxygen consumption of the whole BAT pad. T3 treatment had little effect on phospholipid content and phospholipid fatty acid composition. In contrast, chronic methimazole treatment (hypothyroidism) decreased the BAT pad weight and the triacylglycerol content, but did not significantly change the DNA content in comparison with the control. It significantly decreased the noradrenaline-stimulated BAT oxygen consumption expressed per microg DNA and per BAT pad, but did not change the basal oxygen consumption. Methimazole treatment significantly affected phospholipid content and phospholipid fatty acid composition. Among the major fatty acids of BAT, it decreased docosahexaenoic acid (DHA), arachidonic acid, palmitic acid, palmitoleic acid, and oleic acid, and it increased linoleic acid, stearic acid, and eicosapentaenoic acid. A regression analysis revealed a positive relationship between in vitro respiration and DHA levels in phospholipids (r = 0.404, p<0.05). These results suggest that thyroid hormones have trophic action on BAT and are necessary for BAT thermogenic activity. This study also suggests that DHA is involved in the regulation of BAT thermogenic activity, as we previously indicated. |
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Authors:
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S K Saha; H Ohinata; T Ohno; A Kuroshima |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Japanese journal of physiology Volume: 48 ISSN: 0021-521X ISO Abbreviation: Jpn. J. Physiol. Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1999-02-22 Completed Date: 1999-02-22 Revised Date: 2007-03-21 |
Medline Journal Info:
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Nlm Unique ID: 2985184R Medline TA: Jpn J Physiol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 355-64 Citation Subset: IM |
Affiliation:
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Department of Physiology I, Asahikawa Medical College, Asahikawa, 078-8510, Japan. saha@asahikawa-med.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue, Brown
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metabolism*,
pathology,
physiopathology* Animals Antithyroid Agents / pharmacology Body Temperature Regulation / physiology* Docosahexaenoic Acids / analysis Fatty Acids / analysis* Hyperthyroidism / metabolism, pathology, physiopathology* Hypothyroidism / metabolism, pathology, physiopathology* Male Methimazole / pharmacology Organ Size Oxygen Consumption Phospholipids / chemistry Rats Rats, Wistar Thyroid Hormones / physiology Triiodothyronine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antithyroid Agents; 0/Fatty Acids; 0/Phospholipids; 0/Thyroid Hormones; 25167-62-8/Docosahexaenoic Acids; 60-56-0/Methimazole; 6893-02-3/Triiodothyronine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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