| Thermodynamic study on competitive solubilization of cholesterol and beta-sitosterol in bile salt micelles. | |
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MedLine Citation:
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PMID: 17524379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Differences in the preferential solubilization of cholesterol and competitive solubilizates (beta-sitosterol and aromatic compounds) in bile salt micelles was systematically studied by changing the molar ratio of cholesterol to competitive solubilizates. The cholesterol solubility in a mixed binary system (cholesterol and beta-sitosterol) was almost half that of the cholesterol alone system, regardless of the excess beta-sitosterol quantity added. On the other hand, the mutual solubilities of cholesterol and pyrene were not inhibited by their presence in binary mixed crystals. Finally, the cholesterol solubility was measured by changing the alkyl chain length of n-alkylbenzenes. When tetradecylbenzene was added to the bile solution, the cholesterol solubility decreased slightly and was below the original cholesterol solubility. Based on Gibbs energy change (DeltaG degrees ) for solubilization, chemicals that inhibit cholesterol solubility in their combined crystal systems showed a larger negative DeltaG degrees value than cholesterol alone. |
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Authors:
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Keisuke Matsuoka; Takashi Hirosawa; Chikako Honda; Kazutoyo Endo; Yoshikiyo Moroi; Osamu Shibata |
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Publication Detail:
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Type: Journal Article Date: 2007-04-21 |
Journal Detail:
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Title: Chemistry and physics of lipids Volume: 148 ISSN: 0009-3084 ISO Abbreviation: Chem. Phys. Lipids Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-18 Completed Date: 2007-08-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0067206 Medline TA: Chem Phys Lipids Country: Ireland |
Other Details:
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Languages: eng Pagination: 51-60 Citation Subset: IM |
Affiliation:
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Department of Physical Chemistry, Showa Pharmaceutical University, Higashi-Tamagawagakuen 3-3165, Machida, Tokyo, Japan. matsuoka@ac.shoyaku.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bile Acids and Salts
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chemistry* Chemistry, Physical* / instrumentation, methods Cholesterol / chemistry* Hydrocarbons, Aromatic / chemistry Micelles Sitosterols / chemistry* Solubility Thermodynamics* |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Hydrocarbons, Aromatic; 0/Micelles; 0/Sitosterols; 57-88-5/Cholesterol; 5779-62-4/sitosterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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