| Thermodynamic analysis of amines-lasalocid complex formation. | |
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MedLine Citation:
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PMID: 17029926 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The ionophore lasalocid A selectively transports amines across lipid membranes. Free energy differences of amine-lasalocid complex formation reactions and the activation barriers of the complex transport were calculated by the finite difference thermodynamic integration method. Four catecholamines were treated: serotonin > dopamine > noradrenaline > adrenaline. The concept of transfer selectivity was introduced, combining binding and activation barrier selectivities. The transfer selectivities correlate well with the relative selectivities of the amines under study. |
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Authors:
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V E Khutorsky |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biophysical chemistry Volume: 69 ISSN: 0301-4622 ISO Abbreviation: Biophys. Chem. Publication Date: 1997 Dec |
Date Detail:
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Created Date: 2006-10-10 Completed Date: 2007-07-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0403171 Medline TA: Biophys Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 161-6 Citation Subset: - |
Affiliation:
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Chemistry Department, Ben Gurion University of the Negev, Beer-Sheva, Israel. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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