| Thermodynamic Analysis of the Selectivity Enhancement Obtained by Using Smart Hydrogels That Are Zwitterionic When Detecting Glucose With Boronic Acid Moieties. | |
| | |
MedLine Citation:
|
PMID: 22190765 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Because the boronic acid moiety reversibly binds to sugar molecules and has low cytotoxicity, boronic acid-containing hydrogels are being used in a variety of implantable glucose sensors under development, including sensors based on optical, fluorescence, and swelling pressure measurements. However, some method of glucose selectivity enhancement is often necessary, because isolated boronic acid molecules have a binding constant with glucose that is some forty times smaller than their binding constant with fructose, the second most abundant sugar in the human body. In many cases, glucose selectivity enhancement is obtained by incorporating pendant tertiary amines into the hydrogel network, thereby giving rise to a hydrogel that is zwitterionic at physiological pH. However, the mechanism by which incorporation of tertiary amines confers selectivity enhancement is poorly understood. In order to clarify this mechanism, we use the osmotic deswelling technique to compare the thermodynamic interactions of glucose and fructose with a zwitterionic smart hydrogel containing boronic acid moieties. We also investigate the change in the structure of the hydrogel that occurs when it binds to glucose or to fructose using the technique of small angle neutron scattering. |
| | |
Authors:
|
F Horkay; S H Cho; P Tathireddy; L Rieth; F Solzbacher; J Magda |
Related Documents
:
|
21296915 - Role of carnitine acetyltransferases in acetyl coenzyme a metabolism in aspergillus nid... 8798265 - The very low birth weight premature infant is capable of synthesizing arachidonic and d... 16615355 - Modulation of conjugated linoleic acid-induced loss of chicken egg hatchability by diet... 12030325 - Evidence for [1,5] sigmatropic rearrangements of cla in heated oils. 18961285 - Estimation of allyl alcohol by chloramine-t. 22747885 - Hypolipidemic activity in sprague-dawley rats and constituents of a novel natural veget... |
Publication Detail:
|
Type: JOURNAL ARTICLE |
Journal Detail:
|
Title: Sensors and actuators. B, Chemical Volume: 160 ISSN: 0925-4005 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101149755 Medline TA: Sens Actuators B Chem Country: - |
Other Details:
|
Languages: ENG Pagination: 1363-1371 Citation Subset: - |
Affiliation:
|
Section on Tissue Biophysics and Biomimetics, Program on Pediatric Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-5772 USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
R21 EB008571-01//NIBIB NIH HHS; R21 EB008571-02//NIBIB NIH HHS; R21 EB008571-03//NIBIB NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: GENERATIONAL DIFFERENCES IN COHABITATION AND MARRIAGE IN THE U.S.
Next Document: Multifrequency Pulsed EPR Studies of Biologically Relevant Manganese(II) Complexes.