| Thermodilution cardiac output--are three injections enough? | |
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MedLine Citation:
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PMID: 15504196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Bolus thermodilution cardiac output measurements have been a mainstay in clinical monitoring of critically ill patients for more than 30 years. Usually the results of an arbitrarily chosen number (1-6) of thermal indicator injections are averaged to increase the reliability of the measurement. The number of injections needed to achieve a given level of precision has, however, not previously been systematically investigated. METHODS AND RESULTS: In 80 hemodynamically stable patients cardiac output was determined as the average of eight injections of 10 ml of iced saline. From the 638 measurements we examined the relationship between the number of thermal indicator injections and the precision of the resulting cardiac output estimate. Furthermore, the association between the number of injections and the least detectable difference among two sets of measurements was established. CONCLUSION: The current study shows that one needs to average the results of four injections to be 95% confident that the result is within 5% of the 'true' cardiac output and that two series of four measurements have to differ by at least 7% before one can be sure (95%) that a change in cardiac function has taken place. |
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Authors:
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L B Nilsson; J C Nilsson; L T Skovgaard; P G Berthelsen |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 48 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-10-26 Completed Date: 2005-02-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 1322-7 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Gentofte Hospital, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms Cardiac Output / physiology* Critical Illness Female Hemodynamics / physiology Humans Isotonic Solutions / administration & dosage, diagnostic use Linear Models Male Middle Aged Monitoring, Physiologic Reproducibility of Results Respiration, Artificial Thermodilution / methods* |
| Chemical | |
Reg. No./Substance:
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0/Isotonic Solutions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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