Document Detail

Thermodilution cardiac output--are three injections enough?
MedLine Citation:
PMID:  15504196     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Bolus thermodilution cardiac output measurements have been a mainstay in clinical monitoring of critically ill patients for more than 30 years. Usually the results of an arbitrarily chosen number (1-6) of thermal indicator injections are averaged to increase the reliability of the measurement. The number of injections needed to achieve a given level of precision has, however, not previously been systematically investigated. METHODS AND RESULTS: In 80 hemodynamically stable patients cardiac output was determined as the average of eight injections of 10 ml of iced saline. From the 638 measurements we examined the relationship between the number of thermal indicator injections and the precision of the resulting cardiac output estimate. Furthermore, the association between the number of injections and the least detectable difference among two sets of measurements was established. CONCLUSION: The current study shows that one needs to average the results of four injections to be 95% confident that the result is within 5% of the 'true' cardiac output and that two series of four measurements have to differ by at least 7% before one can be sure (95%) that a change in cardiac function has taken place.
L B Nilsson; J C Nilsson; L T Skovgaard; P G Berthelsen
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  48     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-26     Completed Date:  2005-02-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1322-7     Citation Subset:  IM    
Department of Anesthesiology, Gentofte Hospital, Denmark.
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MeSH Terms
Cardiac Output / physiology*
Critical Illness
Hemodynamics / physiology
Isotonic Solutions / administration & dosage,  diagnostic use
Linear Models
Middle Aged
Monitoring, Physiologic
Reproducibility of Results
Respiration, Artificial
Thermodilution / methods*
Reg. No./Substance:
0/Isotonic Solutions

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