Document Detail


Thermic effect of food and sympathetic nervous system activity in humans.
MedLine Citation:
PMID:  8878356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intake of nutrients is known to increase energy expenditure. Measured thermic effects of nutrient are 0-3% for fat, 5-10% for carbohydrates and 20-30% for proteins. Stimulation of adenosine triphosphate (ATP) hydrolysis during intestinal absorption, initial metabolic steps and nutrient storage are responsible for this food thermic effect. The autonomic nervous system modulates the thermic effect of nutrients. Parasympathetic muscarinic antagonists reduce the thermic effect of orally administered nutrients, most likely by delaying gastric emptying and decreasing the amount of nutrient storage. Antagonists of the beta-adrenoreceptors decrease the thermic effect of glucose. The part of glucose induced thermogenesis which is eliminated by beta-adrenergic antagonists has been called 'facultative thermogenesis' and takes place, at least in part, in skeletal muscle. Insulin-induced stimulation of muscle sympathetic nerve activity may be involved in this facultative thermogenesis. The thermic effect of food is reduced in obese, insulin-resistant patients. The effect of thermogenesis represents about 50-150 kcal/day in such patients, and can explain only a minor part of their excess body weight. Defective thermogenesis may, however, contribute to weight gain, or impair weight loss in such patients.
Authors:
L Tappy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Reproduction, nutrition, development     Volume:  36     ISSN:  0926-5287     ISO Abbreviation:  Reprod. Nutr. Dev.     Publication Date:  1996  
Date Detail:
Created Date:  1996-11-21     Completed Date:  1996-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8913069     Medline TA:  Reprod Nutr Dev     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  391-7     Citation Subset:  IM    
Affiliation:
Institute of Physiology, University of Lausanne, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Autonomic Nervous System / physiology
Body Temperature Regulation*
Food*
Humans
Obesity
Sympathetic Nervous System / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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