Document Detail


Thermal stress and diabetic complications.
MedLine Citation:
PMID:  7698855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Activities of erythrocyte aldose reductase were compared in 34 normal subjects, 45 diabetic patients, and nine young men following immersion in water at 25, 39, and 42 degrees C. Mean basal enzyme activity was 1.11 (SEM 0.12) U/g Hb and 2.07 (SEM 0.14) U/g Hb in normal controls and diabetic patients, respectively (P < 0.0001). Activities of the enzyme showed a good correlation with hemaglobin A1 (HbA1) concentrations (P < 0.01) but not with fasting plasma glucose concentrations. After immersion at 42 degrees C for 10 min, enzyme activity was increased by 37.6% (P < 0.01); however, the activity decreased by 52.2% (P < 0.005) after immersion for 10 min at 39 degrees C and by 47.0% (P < 0.05) at 25 degrees C. These changes suggest that heat stress might aggravate diabetic complications, and body exposure to hot environmental conditions is not recommended for diabetic patients.
Authors:
Y Ohtsuka; N Yabunaka; I Watanabe; H Noro; H Fujisawa; Y Agishi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of biometeorology     Volume:  38     ISSN:  0020-7128     ISO Abbreviation:  Int J Biometeorol     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-04-28     Completed Date:  1995-04-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0374716     Medline TA:  Int J Biometeorol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  57-9     Citation Subset:  IM; S    
Affiliation:
Department of Rehabilitation and Physical Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aldehyde Reductase / blood
Diabetes Mellitus, Type 2 / complications*,  enzymology
Erythrocytes / enzymology
Female
Hot Temperature / adverse effects*
Humans
Immersion / adverse effects
Male
Middle Aged
Stress, Physiological / complications,  enzymology
Chemical
Reg. No./Substance:
EC 1.1.1.21/Aldehyde Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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