Document Detail

Thermal sintering: a novel technique used in the design, optimization and biopharmaceutical evaluation of propranolol HCl gastric floating tablets.
MedLine Citation:
PMID:  23317339     Owner:  NLM     Status:  Publisher    
Abstract The objective of the present investigation was to study the applicability of thermal sintering technique for the development of gastric floating tablets of propranolol HCl. Formulations were prepared using four independent variables, namely (i) polymer quantity, (ii) sodium bicarbonate concentration, (iii) sintering temperature and (iv) sintering time. Floating lag time and t(95) were taken as dependent variables. Tablets were prepared by the direct compression method and were evaluated for physicochemical properties, in vitro buoyancy and dissolution studies. From the drug release studies, it was observed that drug retarding property mainly depends upon the sintering temperature and time of exposure. The statistically optimized formulation (PTSso) was characterized by Fourier transform infrared spectroscopy and differential scanning calorimetry studies, and no significant chemical interaction between drug and polymer was observed. Optimized formulation was stable at accelerated conditions for a period of six months. PTSso was evaluated for in vivo buoyancy studies in humans for both fed and fasted states and found that gastric residence time of the floating tablets were enhanced by fed stage but not in fasted state. Optimized formulation PTSso and commercial formulation Ciplar LA 80 were subjected to bioavailability studies in healthy human volunteers by estimating pharmacokinetic parameters such as C(max), T(max), area under curve (AUC)(,) elimination rate constant (K(el)), biological half-life (t(1/2)) and mean residence time (MRT). There was a significant increase in the bioavailability of the propranolol HCl from PTSso formulation, which was evident from increased AUC levels and larger MRT values than Ciplar LA 80.
Meka Venkata Srikanth; Ambedkar Sunil Songa; Sreenivasa Rao Nali; Janaki Ram Battu; Venkata Ramana Murthy Kolapalli
Related Documents :
1668809 - Dose-dependent stimulation of adenylate cyclase in rat hippocampal tissue by isoprenali...
15798369 - Novel routes for metabolism of 7-ketocholesterol.
697279 - Responsiveness of the rabbit eye to adrenergic and cholinergic agonists after treatment...
2866839 - Beta-adrenergic blockade. an update.
14228129 - The selectivity of drugs blocking ganglionic transmission in the rat.
23317339 - Thermal sintering: a novel technique used in the design, optimization and biopharmaceut...
17249 - Prevalence of drugs among drivers arrested for drinking and driving in finland.
9695719 - Inhibition of cyp2e1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics i...
17890079 - Endpoints and other considerations in phase i studies of targeted anticancer therapy: r...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  -     ISSN:  1520-5762     ISO Abbreviation:  Drug Dev Ind Pharm     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
School of Pharmacy, International Medical University , Kuala Lumpur , Malaysia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Investigation of the mechanisms of improved oral bioavailability of bergenin using bergenin-phosphol...
Next Document:  Bee venom acupuncture for the treatment of chronic low back pain: study protocol for a randomized, d...