| Thermal responses of ex vivo human skin during multiple cryogen spurts and 1,450 nm laser pulses. | |
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MedLine Citation:
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PMID: 16493678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Although cryogen spray cooling (CSC) is used to minimize the risk of epidermal damage during laser dermatologic surgery, concern has been expressed that CSC may induce cryo-injury. The objective of this study is to measure temperature variations at the epidermal-dermal junction in ex vivo human skin during three clinically relevant multiple cryogen spurt-laser pulse sequences (MCS-LPS). STUDY DESIGN/MATERIALS AND METHODS: The epidermis of ex vivo human skin was separated from the dermis and a thin-foil thermocouple (13 microm thickness) was inserted between the two layers. Thermocouple depth and epidermal thickness were measured using optical coherence tomography (OCT). Skin specimens were preheated to 30 degrees C before the MCS-LPS were initiated. Three MCS-LPS patterns, with total cryogen spray times of 38, 30, and 25 milliseconds respectively, were applied to the specimens in combination with laser fluences of 10 and 14 J/cm(2), while the thermocouple recorded the temperature changes at the epidermal-dermal junction. RESULTS: The thermocouple effectively recorded fast temperature changes during three MCS-LPS patterns. The lowest temperatures measured corresponded to the sequences with longer pre-cooling cryogen spurts. No sub-zero temperatures were measured for any of the MCS-LPS patterns under study. CONCLUSIONS: The three clinically relevant MCS-LPS patterns evaluated in this study do not cause sub-zero temperatures in ex vivo human skin at the epidermal-dermal junction and, therefore, are unlikely to cause significant cryogen induced epidermal injury. |
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Authors:
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Rong Zhang; Julio C Ramirez-San-Juan; Bernard Choi; Wangcun Jia; Guillermo Aguilar; Kristen M Kelly; J Stuart Nelson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Lasers in surgery and medicine Volume: 38 ISSN: 0196-8092 ISO Abbreviation: Lasers Surg Med Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-02-28 Completed Date: 2006-06-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8007168 Medline TA: Lasers Surg Med Country: United States |
Other Details:
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Languages: eng Pagination: 137-41 Citation Subset: IM |
Copyright Information:
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Copyright 2005 Wiley-Liss, Inc. |
Affiliation:
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Beckman Laser Institute, University of California, Irvine, 92612, USA. zhangr@uci.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerosols Cryotherapy / methods* Dermis / radiation effects Epidermis / radiation effects Humans Laser Therapy / methods* Skin Temperature / radiation effects* Thermography |
| Grant Support | |
ID/Acronym/Agency:
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AR47551/AR/NIAMS NIH HHS; AR48458/AR/NIAMS NIH HHS; EB002495/EB/NIBIB NIH HHS; HD42057/HD/NICHD NIH HHS; RR01192/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aerosols |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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