Document Detail


Thermal hypersensitivity in a subset of irritable bowel syndrome patients.
MedLine Citation:
PMID:  19598301     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To characterize thermal hypersensitivity in patients with constipation- and diarrhea-predominant irritable bowel syndrome (IBS).
METHODS: Thermal pain sensitivity was tested among patients with diarrhea-predominant IBS (D-IBS) and constipation-predominant IBS (C-IBS) compared to healthy subjects. A total of 42 patients (29 female and 13 male; mean age 27.0 +/- 6.4 years) with D-IBS; 24 patients (16 female and eight male; mean age 32.5 +/- 8.8 years) with C-IBS; and 52 control subjects (34 female and 18 male; mean age 27.3 +/- 8.0 years) participated in the study. Thermal stimuli were delivered using a Medoc Thermal Sensory Analyzer with a 3 cm x 3 cm surface area. Heat pain threshold (HPTh) and heat pain tolerance (HPTo) were assessed on the left ventral forearm and left calf using an ascending method of limits. The Functional Bowel Disease Severity Index (FBDSI) was also obtained for all subjects.
RESULTS: Controls were less sensitive than C-IBS and D-IBS (both at P < 0.001) with no differences between C-IBS and D-IBS for HPTh and HPTo. Thermal hyperalgesia was present in both groups of IBS patients relative to controls, with IBS patients reporting significantly lower pain threshold and pain tolerance at both test sites. Cluster analysis revealed the presence of subgroups of IBS patients based on thermal hyperalgesia. One cluster (17% of the sample) showed a profile of heat pain sensitivity very similar to that of healthy controls; a second cluster (47% of the sample) showed moderate heat pain sensitivity; and a third cluster (36% of the sample) showed a very high degree of thermal hyperalgesia.
CONCLUSION: A subset of IBS patients had thermal hypersensitivity compared to controls, who reported significantly lower HPTh and HPTo. All IBS patients had a higher score on the FBDSI than controls. Interestingly, the subset of IBS patients with high thermal sensitivity (36%) had the highest FBDSI score compared to the other two groups of IBS patients.
Authors:
Qiqi Zhou; Roger B Fillingim; Joseph L Riley; G Nicholas Verne
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  15     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-14     Completed Date:  2009-09-10     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  3254-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cluster Analysis
Constipation / physiopathology
Diarrhea / physiopathology
Female
Humans
Hyperalgesia / physiopathology*
Irritable Bowel Syndrome / physiopathology*
Male
Pain Measurement
Pain Threshold
Young Adult
Grant Support
ID/Acronym/Agency:
R01 NS053090-04/NS/NINDS NIH HHS; R01 NS053090-05/NS/NINDS NIH HHS; R01-NS053090/NS/NINDS NIH HHS
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