| Thermal homeostasis in rats after intrahypothalamic injections of 6-hyroxydopamine. | |
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MedLine Citation:
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PMID: 1267027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Specific destruction of at least 90% of the noradrenergic neurons in the preoptic/anterior hypothalamic region (PO/AH) by local injection of 9-hyroxydopamine (6-HDA) did not disrupt thermoregulation by rats either in the heat or the cold. Examination of the multiple effector mechanisms suggested that thermal balance was maintained in a normal fashion, and that compensatory adjustments did not conceal individual dysfunctions. In contrast with the ineffectual 6-HDA lesions of the PO/AH were the outstanding impairments seen in rats following electrolytic lesions of this area. All the latter animals became severely hyperthermic during the 1st h of exposure to an ambient temperature of 40 degrees C, and half of them were additionally unable to maintain body temperatures when exposed to an ambient temperature of 6 degrees C. The electrolytic lesions reduced norepinephrine levels in the PO/AH, but the 50-70% depletions were substantially smaller than those found in 6-HDA-treated rats. These results raise new doubts about whether central noradrenergic fibers have an important role in the regulation of body temperature by rats. |
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Authors:
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J G Van Zoeren; E M Stricker |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 230 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1976 Apr |
Date Detail:
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Created Date: 1976-07-06 Completed Date: 1976-07-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 932-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Body Temperature Regulation / drug effects* Electric Injuries Electrodes Electrophysiology Hydroxydopamines / administration & dosage, pharmacology* Hypothalamus / physiology* Hypothalamus, Anterior / physiology* Injections, Intraventricular Male Oxygen Consumption Preoptic Area / physiology* Rats |
| Chemical | |
Reg. No./Substance:
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0/Hydroxydopamines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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