| Thermal effects on ventilation in cats: participation of carotid body chemoreceptors. | |
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MedLine Citation:
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PMID: 1759053 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In pentobarbitone anesthetized cats, raising body temperature from 37 to 40 degrees C by external heat increased respiratory frequency, tidal volume, frequency of spontaneous gasps and mean inspiratory flow. It reduced end-tidal CO2 pressure, together with inspiratory and expiratory durations. After bilateral section of the carotid nerves, raising body temperature still induced hyperventilation, but the increase in gasp frequency was less pronounced and no significant change in tidal volume was observed. In comparison to steady ventilatory values in the intact condition, significant reductions in tidal volume at 38 degrees C and in gasp frequency at 37, 39 and 40 degrees C were observed after bilateral carotid neurotomy. Brief hyperoxic tests induced transient decreases in tidal volume and increases in end-tidal CO2 pressure which were significantly larger at 40 degrees C than at 37 degrees C. These changes disappeared after bilateral carotid neurotomy. Anesthetic block of both carotid nerves produced transient reductions in tidal volume at any given temperature. We conclude that carotid body afferents contribute to the hyperventilation evoked by hyperthermia. After their interruption, such contribution is replaceable from other thermal afferents. |
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Authors:
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R Fadic; C Larrain; P Zapata |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Respiration physiology Volume: 86 ISSN: 0034-5687 ISO Abbreviation: Respir Physiol Publication Date: 1991 Oct |
Date Detail:
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Created Date: 1992-02-06 Completed Date: 1992-02-06 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0047142 Medline TA: Respir Physiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 51-63 Citation Subset: IM |
Affiliation:
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Laboratory of Neurobiology, Catholic University of Chile, Santiago. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Carotid Body / physiology, ultrastructure* Cats Chemoreceptor Cells / physiology* Fever / physiopathology Hot Temperature* Hyperventilation / physiopathology Inspiratory Reserve Volume / physiology Respiration / physiology* Tidal Volume / physiology Ventilation-Perfusion Ratio |
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