Document Detail

Thermal destruction of folacin in microwave and conventional heating.
MedLine Citation:
PMID:  701671     Owner:  NLM     Status:  MEDLINE    
Folacin derivatives were found to vary greatly in thermal stability. It is worth mention that pteroylmonoglutamic acid (PGA), the folate used therapeutically and in food supplementation, was extremely stable to heat under the experimental conditions, that is, at 100 degrees C. in neutral solution. Under these conditions, 5-formyl-THFA also exhibited marked stability; neither form was affected significantly by microwave radiation. In view of the increasing data indicating the abundance of 5-methyl-THFA and other derivatives of THFA in foods, the thermal lability of these forms was especially interesting. THFA was found to be an extremely labile folate, while 5-methyl-THFA had intermediate stability among the forms tested. Microwave heating of 5-methyl-THFA resulted in a faster rate of degradation than conventional heating at the same temperature. The mechanism of this action needs further research.
R G Cooper; T S Chen; M A King
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the American Dietetic Association     Volume:  73     ISSN:  0002-8223     ISO Abbreviation:  J Am Diet Assoc     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1978-12-27     Completed Date:  1978-12-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7503061     Medline TA:  J Am Diet Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  406-10     Citation Subset:  AIM; IM    
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MeSH Terms
Drug Stability
Folic Acid* / analogs & derivatives
Hot Temperature*
Reg. No./Substance:
0/Formyltetrahydrofolates; 0/Tetrahydrofolates; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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