Document Detail


Thermal characterization of citric acid solid dispersions with benzoic acid and phenobarbital.
MedLine Citation:
PMID:  430499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The glass transition temperatures of citric temperatures of citric acid glass were determined by differential scanning calorimetry to be 10.2 and 13.5 degrees for in situ and bulk-prepared samples, respectively. Mechanical stress on citric acid glass induced foci for crystallization. Benzoic acid addition to citric acid glass decreased its glass transition temperature while phenobarbital addition increased its glass transition temperature, the latter forming a glass solution.
Authors:
R J Timko; N G Lordi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  68     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-06-29     Completed Date:  1979-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  601-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Benzoates*
Calorimetry, Differential Scanning
Citrates*
Glass
Magnetic Resonance Spectroscopy
Phenobarbital*
Suspensions
Thermodynamics
X-Ray Diffraction
Chemical
Reg. No./Substance:
0/Benzoates; 0/Citrates; 0/Suspensions; 50-06-6/Phenobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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