Document Detail

Thermal characteristics of a hepatic cryolesion formed in vitro by a 3-mm implantable cryoprobe.
MedLine Citation:
PMID:  9527875     Owner:  NLM     Status:  MEDLINE    
The objective of the investigation was to characterize the hepatic cryolesion formed with an implantable needle (3 x 100 mm) cryoprobe. This was used to produce cryolesions in isolated porcine liver tissue equilibrated to 37 degrees C in a water bath. The shape, size, and temperature zones within the cryolesion and the effect of single versus repeated freeze-thaw cycles on cryolesion size were studied. The final shape of the cryolesion at 15-20 min freezing was cylindrical and its distal hemispherical end extended 8 mm beyond the tip of the cryoprobe. The rate of increase in maximum diameter was logarithmic and decreased from 4.7 mm/min during the first 5 min to 0.4 mm/min during the fourth 5-min period of freezing. By contrast, the rate of increase in volume was linear and ranged from 9.6 to 7.9 ml/min during the corresponding periods. The volume of the hepatic cryolesion after 20 min of continuous freezing was significantly greater than that of the cryolesion formed with 20 min of cumulative freezing interrupted by a 5-min spontaneous thaw. The ultimate temperatures reached and the cooling rates varied in different zones within the cryolesion depending on distances away from and alongside the cryoprobe. Diameter measurements taken in isolation do not reflect the actual growth rate of the cryolesion. Volume measurements define more accurately the amount of tissue frozen and left in situ. Prolonged freezing beyond 20 min did not increase the diameter of the cryolesion. A single continuous freeze produces a larger cryolesion than two freeze-thaw cycles of the same freezing duration.
C M Lam; S M Shimi; A Cuschieri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cryobiology     Volume:  36     ISSN:  0011-2240     ISO Abbreviation:  Cryobiology     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-05-20     Completed Date:  1998-05-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0006252     Medline TA:  Cryobiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  156-64     Citation Subset:  IM    
Copyright Information:
Copyright 1998 Academic Press.
Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland.
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