Document Detail

Thermal stability and decomposition kinetic studies of acyclovir and zidovudine drug compounds.
MedLine Citation:
PMID:  23299688     Owner:  NLM     Status:  MEDLINE    
Investigations on thermal behavior of drug samples such as acyclovir and zidovudine are interesting not only for obtaining stability information for their processing in pharmaceutical industry but also for predicting their shelf lives and suitable storage conditions. The present work describes thermal behaviors and decomposition kinetics of acyclovir and zidovudine in solid state, studied by some thermal analysis techniques including differential scanning calorimetry (DSC) and simultaneous thermogravimetry-differential thermal analysis (TG/DTA). TG analysis revealed that thermal degradation of the acyclovir and zidovudine is started at the temperatures of 400°C and 190°C, respectively. Meanwhile, TG-DTA analysis of acyclovir indicated that this drug melts at about 256°C. However, melting of zidovudine occurred at 142°C, which is 100°C before starting its decomposition (242°C). Different heating rates were applied to study the DSC behavior of drug samples in order to compute their thermokinetic and thermodynamic parameters by non-isothermal kinetic methods. Thermokinetic data showed that both drugs at the room temperature have slow degradation reaction rates and long shelf lives. However, acyclovir is considerably more thermally stable than zidovudine.
Mojtaba Shamsipur; Seied Mahdi Pourmortazavi; Ali Akbar Miran Beigi; Rouhollah Heydari; Mina Khatibi
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Publication Detail:
Type:  Journal Article     Date:  2013-01-09
Journal Detail:
Title:  AAPS PharmSciTech     Volume:  14     ISSN:  1530-9932     ISO Abbreviation:  AAPS PharmSciTech     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-08-12     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  100960111     Medline TA:  AAPS PharmSciTech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  287-93     Citation Subset:  IM    
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MeSH Terms
Acyclovir / chemistry*
Antiviral Agents / chemistry*
Calorimetry, Differential Scanning
Drug Stability
Zidovudine / chemistry*
Reg. No./Substance:
0/Antiviral Agents; 4B9XT59T7S/Zidovudine; X4HES1O11F/Acyclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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