Document Detail


Behavioral, thermal and neurochemical effects of acute and chronic 3,4-methylenedioxymethamphetamine ("Ecstasy") self-administration.
MedLine Citation:
PMID:  19891989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
3,4-Methylenedioxymethamphetamine (MDMA) is a popular methamphetamine derivative associated with young adults and all-night dance parties. However, the enduring effects of MDMA at voluntary intake levels have not been extensively investigated. In this study, MDMA-influenced behaviors and core temperatures were assessed over the course of 20 daily MDMA self-administration sessions in rats. In vivo microdialysis techniques were used in a subsequent MDMA challenge test session to determine extracellular nucleus accumbens dopamine (NAcc DA) and serotonin (5-HT) levels in MDMA-experienced and naïve animals before and after a self-administered MDMA injection (3.0mg/kg, i.v.). During self-administration sessions, gradual and significant increases in MDMA intake and MDMA-stimulated locomotor activity were observed across sessions. Core temperature significantly decreased during initial MDMA sessions, but was unaltered by the last 10 sessions. In the MDMA challenge test, MDMA-naïve rats showed significantly higher NAcc 5-HT responses compared to MDMA-experienced rats, though MDMA experience did not affect the magnitude of NAcc DA response. The overall findings suggest that changes in MDMA-induced responses over the course of increasing levels of drug exposure may reflect the development of tolerance to a number of MDMA effects.
Authors:
Maria Elena Reveron; Esther Y Maier; Christine L Duvauchelle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-03
Journal Detail:
Title:  Behavioural brain research     Volume:  207     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-13     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  500-7     Citation Subset:  IM    
Copyright Information:
Published by Elsevier B.V.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects*
Body Temperature / drug effects*
Catheterization
Conditioning, Operant / drug effects
Dopamine / metabolism
Drug Tolerance
Extracellular Space / drug effects,  metabolism
Hallucinogens / administration & dosage,  pharmacology*
Male
Microdialysis
Motor Activity / drug effects
N-Methyl-3,4-methylenedioxyamphetamine / administration & dosage,  pharmacology*
Nucleus Accumbens / drug effects*,  metabolism*
Rats
Rats, Sprague-Dawley
Self Administration
Serotonin / metabolism
Time Factors
Grant Support
ID/Acronym/Agency:
R01 DA014640/DA/NIDA NIH HHS; R01 DA014640-05/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Hallucinogens; 333DO1RDJY/Serotonin; KE1SEN21RM/N-Methyl-3,4-methylenedioxyamphetamine; VTD58H1Z2X/Dopamine
Comments/Corrections

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