Document Detail


There's More Than One Way to Scan a Cat: Imaging Cat Auditory Cortex with High-Field fMRI using Continuous or Sparse Sampling.
MedLine Citation:
PMID:  24389047     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
When conducting auditory investigations using functional magnetic resonance imaging (fMRI), there are inherent potential confounds that need to be considered. Traditional continuous fMRI acquisition methods produce sounds >90dB which compete with stimuli or produce neural activation masking evoked activity. Sparse scanning methods insert a period of reduced MRI-related noise, between image acquisitions, in which a stimulus can be presented without competition. In this study, we compared sparse and continuous scanning methods to identify the optimal approach to investigate acoustically-evoked cortical, thalamic and midbrain activity in the cat. Using a 7T magnet, we presented broadband noise, 10kHz tones, or 0.5kHz tones in a block design, interleaved with blocks in which no stimulus was presented. Continuous scanning resulted in larger clusters of activation and more peak voxels within the auditory cortex. However, no significant activation was observed within the thalamus. Also, there was no significant difference found, between continuous or sparse scanning, in activations of midbrain structures. Higher magnitude activations were identified in auditory cortex compared to the midbrain using both continuous and sparse scanning. These results indicate that continuous scanning is the preferred method for investigations of auditory cortex in the cat using fMRI. Also, choice of method for future investigations of midbrain activity should be driven by other experimental factors, such as stimulus intensity and task performance during scanning.
Authors:
Amee J Hall; Trecia A Brown; Jessica A Grahn; Joseph S Gati; Pam L Nixon; Sarah M Hughes; Ravi S Menon; Stephen G Lomber
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-2
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  -     ISSN:  1872-678X     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier B.V.
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