Document Detail


Is There a Role for Fatty Acid Synthase in the Diagnosis of Prostatic Adenocarcinoma?: A Comparison With AMACR.
MedLine Citation:
PMID:  21757596     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Our aim was to compare the usefulness of fatty acid synthase (FASn) with that of α-methylacyl coenzyme-A racemase (AMACR) in the diagnosis of prostatic adenocarcinoma. The expression of these 2 markers was compared in a tissue microarray containing 62 foci of benign glands and 36 foci of prostatic adenocarcinoma. Similar to AMACR, there was significantly higher FASn expression in adenocarcinoma compared with that in benign glands. The optimal accuracy rate and area under curve (AUC) by receiver operating characteristic analysis for FASn were not significantly different from those for AMACR (accuracy, 80% vs 87%; AUC, 0.942 vs 0.956; P for both, > .05). Moreover, in cases with coexistent malignant and benign glands on the same core, FASn could selectively distinguish a proportion of cases (17/21 [81%]) similar to using AMACR. We conclude that FASn may aid in the diagnosis of prostatic adenocarcinoma, at least to supplement AMACR as another positive marker of carcinoma and potentially increase diagnostic accuracy.
Authors:
Xiaojun Wu; Majd Zayzafoon; Xinzhi Zhang; Omar Hameed
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  136     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  239-46     Citation Subset:  AIM; IM    
Affiliation:
Dept of Pathology, Vanderbilt University Medical Center, 1211 Medical Center Dr, 3020D VUH, Nashville, TN 37232-7415; omar.hameed@vanderbilt.edu.
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