| Is There a Need for Dedicated Bone Imaging in Addition to 18F-FDG PET/CT Imaging in Pediatric Sarcoma Patients? | |
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MedLine Citation:
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PMID: 22134608 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE:: Many children with sarcomas undergo whole body 2-deoxy-2-(F)fluoro-D-glucose positron emission tomography/computed tomography (F-FDG PET/CT) and technetium methylene diphosphonate (Tc-MDP) studies. It is unknown whether the combination of both tests results in more accurate detection of bone lesions than F-FDG- PET/CT alone. METHODS:: Tc-MDP bone and F-FDG PET/CT scans were each read by 2 "blinded" observers and then reviewed side-by-side by 3 readers. Bone lesions were graded qualitatively on a 5-point scale (from benign to malignant). Clinical and imaging follow-up (n=21) and bone biopsy results (n=8) served as reference standard. RESULTS:: A total of 39 paired Tc-MDP and F-FDG-PET/CT studies (cases) performed at a mean interval 4±7 days, were performed on 29 patients (mean age 12±5 y). Of these, 21 patients (72%) had bone sarcoma, whereas 8 patients (28%) had soft tissue sarcoma. By patient and case-based analysis, F-FDG PET/CT had an accuracy of 100%. Tc-MDP had accuracies of 90% and 82% by patient and case-based analysis. The combined interpretation had an accuracy of 97%. CONCLUSIONS:: In this study, Tc-MDP bone imaging does not provide an added diagnostic value for bone involvement over F-FDG-PET/CT. |
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Authors:
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Franziska Walter; Johannes Czernin; Theodore Hall; Martin Allen-Auerbach; Martin A Walter; Simone Dunkelmann; Noah Federman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-29 |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: - ISSN: 1536-3678 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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*Department of Molecular and Medical Pharmacology, University of California Los Angeles †Ahmanson Translational Imaging Division ‡Department of Radiology, David Geffen School of Medicine at UCLA §Institute of Nuclear Medicine, University Hospital Basel ∥Institute of Nuclear Medicine, University Hospital Rostock ¶Department of Pediatrics, Division of Hematology/Oncology, Mattel Children's Hospital, David Geffen School of Medicine at UCLA, Los Angeles, CA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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