Document Detail


Therapy with statins in patients with refractory rheumatic diseases: a preliminary study.
MedLine Citation:
PMID:  12945719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have explored the therapeutic potential of statins in patients with different inflammatory rheumatic diseases refractory to conventional therapy. We found that simvastatin (80mg o.d. for eight days) induced a rapid and significant reduction in proteinuria levels in three systemic lupus erythematosus (SLE) patients. A similar kind of therapy had a marked beneficial effect in a patient with Wegener's granulomatosis and a patient with erythema nodosum. On the other hand, five patients with rheumatoid arthritis (RA) who received atorvastatin for eight days (20mg/day) showed reduction in C-reactive protein levels and a clinical improvement that was classified as an ACR20 response. Prior to the administration of statins, all these patients had received aggressive conventional therapy with no satisfactory response. A significant reduction in spontaneous apoptosis of peripheral blood lymphocytes and expression of CD69 and HLA-DR was observed in SLE patients after simvastatin therapy. These results prompted us to perform a pilot short-time comparative (simvastatin versus chloroquine) open clinical trial in 15 patients with RA who were receiving methotrexate as a single disease modifying antirheumatic drug with no satisfactory response. Most patients (9/10) who received simvastatin (40mg/day) showed an ACR50 or better response after eight weeks, whereas such a response was not observed in any patient (0/5) treated with chloroquine. Our preliminary results indicate that statins may be an important therapeutic tool for the treatment of inflammatory rheumatic diseases.
Authors:
C Abud-Mendoza; H de la Fuente; E Cuevas-Orta; L Baranda; J Cruz-Rizo; R González-Amaro
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Lupus     Volume:  12     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2003  
Date Detail:
Created Date:  2003-08-29     Completed Date:  2005-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  607-11     Citation Subset:  IM    
Affiliation:
Unidad Regional de Reumatología y Osteoporosis, Hospital Central, San Luis Potosí, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antirheumatic Agents / therapeutic use
Biological Markers / blood
Blood Sedimentation / drug effects
C-Reactive Protein / drug effects,  metabolism
Child
Chloroquine / therapeutic use
Dose-Response Relationship, Drug
HLA-DR Antigens / drug effects,  metabolism
Heptanoic Acids / therapeutic use
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage,  adverse effects,  therapeutic use*
Leukocytes, Mononuclear / drug effects
Lupus Erythematosus, Systemic / drug therapy,  metabolism
Middle Aged
Proteinuria / chemically induced,  metabolism
Pyrroles / therapeutic use
Rheumatic Diseases / drug therapy*,  metabolism
Rheumatic Fever / drug therapy,  metabolism
Simvastatin / therapeutic use
Treatment Outcome
Wegener Granulomatosis / drug therapy,  metabolism
Chemical
Reg. No./Substance:
0/Antirheumatic Agents; 0/Biological Markers; 0/HLA-DR Antigens; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 110862-48-1/atorvastatin; 54-05-7/Chloroquine; 79902-63-9/Simvastatin; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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