| Therapy with nCPAP: incomplete elimination of Sleep Related Breathing Disorder. | |
| | |
MedLine Citation:
|
PMID: 11153593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Correct assessment of the overall treatment effectiveness requires knowledge about therapy compliance and efficacy. This study aimed to determine overall long-term apnoea alleviation after continuous positive airway pressure (CPAP) in a complete sleep laboratory cohort. Out of 209 consecutive CPAP candidates (mean age 57+/-12 yrs, body mass index (BMI) 30.0+/-5.1 kg x m2, respiratory disturbance index (RDI) 32.9+/-29 h), follow-up treatment was performed in 149 of them at 9, 18 and 30 months after CPAP prescription. Compliance with CPAP (machine run time/days CPAP available) was adjusted for the individual subjective sleep-time. Apnoea alleviation was defined as adjusted compliance multiplied by the CPAP effect (RDI with CPAP applied), remaining RDI was calculated. The baseline RDI, age or BMI in 75 patients, who did not tolerate nasal continuous positive airway pressure (nCPAP), did not differ from those accepting CPAP (acceptors, n=74). In acceptors at 9 months follow-up RDI with CPAP applied was 1.4+/-2.6 (CPAP effect, n=66), mean CPAP use was 3.6+/-2.5 x 24 h(-1) (n=68), mean apnoea alleviation was 52.4+/-32.0% (range 1-100%, n=47), the average remaining whole-night RDI was 17.8+/-26. At 9, 18 and 30 months (n=47), the mean daily CPAP use increased from 3.6+/-2.5 h to 4.1+/-2.5 h and 4.4+/-2.4 h (p<0.01). Effectiveness of continuous positive airway pressure is potentially high but acceptance was low. When accounting for sleep-time, its actual effect and use, only 50% adjusted continuous positive airway pressure effectiveness was observed. |
| | |
Authors:
|
L Grote; J Hedner; R Grunstein; H Kraiczi |
Related Documents
:
|
16645443 - Comparison of mucosal pressures induced by cuffs of different airway devices. 8322243 - Effects of posture on carbon dioxide responsiveness in patients with obstructive sleep ... 715683 - Pharmacological vs. mechanical reduction in portal pressure: a comparative study. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The European respiratory journal Volume: 16 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 2000 Nov |
Date Detail:
|
Created Date: 2001-01-10 Completed Date: 2001-03-22 Revised Date: 2013-05-23 |
Medline Journal Info:
|
Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Denmark |
Other Details:
|
Languages: eng Pagination: 921-7 Citation Subset: IM |
Affiliation:
|
Dept of Clinical Pharmacology and Sleep Laboratory, Sahlgrenska University Hospital, Göteborg, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Body Mass Index Cohort Studies Female Follow-Up Studies Humans Male Middle Aged Patient Compliance Positive-Pressure Respiration* Respiration Retrospective Studies Sleep Sleep Apnea Syndromes / physiopathology, therapy* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An auto-continuous positive airway pressure device controlled exclusively by the forced oscillation ...
Next Document: Effects of mandibular advancement on respiratory resistance.