Document Detail


Therapy of vascular dementias.
MedLine Citation:
PMID:  15207419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vascular dementia (VD) has not to be considered anymore as a univocal nosologic entity. Based on different types of lesions, distinct subtypes of vascular dementia may be identified, each caused by diverse pathophysiological mechanisms. Among these subtypes subcortical vascular dementia (SVD) may represent a well-defined entity in terms of pathophysiology, clinical features and neuroradiological aspects. The picture is characterized by history of arterial hypertension and other vascular risk factors, clinical symptoms and signs including, besides dementia, dysfunctions related to subcortical-frontal circuit damages, and extensive confluent or diffuse abnormalities in the subcortical brain white matter, small deep infarcts as revealed by computed tomographic (CT) or magnetic resonance imaging (MRI) scans. The homogeneity of this clinical-pathological picture is essential for the success of controlled clinical trials in the field of vascular dementia.
Authors:
D Inzitari; M Lamassa; L Pantoni; A M Basile
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Archives of gerontology and geriatrics. Supplement     Volume:  -     ISSN:  0924-7947     ISO Abbreviation:  Arch Gerontol Geriatr Suppl     Publication Date:  2004  
Date Detail:
Created Date:  2004-06-21     Completed Date:  2004-10-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8911786     Medline TA:  Arch Gerontol Geriatr Suppl     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  229-34     Citation Subset:  IM    
Affiliation:
Dipartimento di Scienze Neurologiche e Psichiatriche, Università degli Studi di Firenze, I-50134 Firenze, Italy. inzitari@neuro.unifi.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Brain / pathology,  physiopathology*,  radiography
Cognition Disorders / diagnosis,  epidemiology
Dementia, Vascular / drug therapy*,  epidemiology,  physiopathology*
Double-Blind Method
Humans
Hypertension / epidemiology
International Classification of Diseases
Magnetic Resonance Imaging
Nerve Net / pathology,  physiopathology
Nimodipine / therapeutic use*
Risk Factors
Severity of Illness Index
Tomography, X-Ray Computed
Vasodilator Agents / therapeutic use*
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 66085-59-4/Nimodipine

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