Document Detail


Therapy for urolithiasis with hydroxamic acids. IV. Prevention of infected urinary stone formation with N-(pivaloyl)glycinohydroxamic acid.
MedLine Citation:
PMID:  7028944     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
With the aim of finding a prospective therapeutic compound with a promising potential for the treatment of urolithiasis, we evaluated the effectiveness of a new potent inhibitor of urease, N-(pivaloyl)glycinohydroxamic acid. The present study revealed that N-(pivaloyl)glycinohydroxamic acid effectively inhibited the alkalinization of urine and the stone formation in vitro and in vivo, due to its strong inhibitory potency against the ureolytic activity of intact Proteus mirabilis. The possibility of the clinical application of this compound in the prevention of struvite stone formation caused by infection of urea-splitting bacteria awaits evaluation of the safety of this compound.
Authors:
M Satoh; K Munakata; K Kitoh; N Seto; T Kanazawa; H Takeuchi; O Yoshida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmacobio-dynamics     Volume:  4     ISSN:  0386-846X     ISO Abbreviation:  J. Pharmacobio-dyn.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1982-01-20     Completed Date:  1982-01-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7901854     Medline TA:  J Pharmacobiodyn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  469-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Hydrogen-Ion Concentration
Hydroxamic Acids / pharmacology,  therapeutic use*
Male
Proteus Infections / complications
Proteus mirabilis / drug effects
Rats
Urease / antagonists & inhibitors*
Urinary Calculi / microbiology,  prevention & control*
Urine / analysis
Chemical
Reg. No./Substance:
0/Hydroxamic Acids; 73912-85-3/N-(pivaloyl)glycinohydroxamic acid; EC 3.5.1.5/Urease

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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