| Therapy-resistant leg ulcer in a patient with Rothmund-Thomson syndrome. | |
| | |
MedLine Citation:
|
PMID: 20860557 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Rothmund-Thomson syndrome (RTS) is a rare genodermatosis with characteristic skin changes such as atrophy, abnormal pigmentation and telengiectasias, skeletal abnormalities, short stature, juvenile cataract and predisposition to skin and bone malignancies. Data from the literature suggest that cutaneous findings of the syndrome include genetically programmed ageing changes and DNA repair abnormalities related to photosensitivity. Our patient is a 23-year-old male who presented with an unhealing ulcer for one and a half year on his left leg. Although he had received many various treatments, there had been no significant improvement during this period. We believe that this failure of healing might be to DNA repair abnormalities of fibroblasts. To our knowledge, this is the first case reported with coexistence of an unhealing ulcer without any findings of malignancy and RTS. |
| | |
Authors:
|
Ilknur Altunay; Neslihan Fisek; Gonca Gokdemir; Damlanur Sakız; Umran Cetincelik |
Related Documents
:
|
2709287 - Gastroesophageal dysfunction in cornelia de lange syndrome. 8219107 - A patient with tn syndrome associated with myelodysplastic syndrome showed abnormal gly... 10756427 - A variant of cenani-lenz type syndactyly. 572507 - Familial kearns-sayre syndrome. 16122637 - Reverse shapiro's syndrome--an unusual cause of fever of unknown origin. 15902477 - Herniation through the foramen of winslow presenting as obstructive jaundice. |
Publication Detail:
|
Type: Journal Article Date: 2010-09-21 |
Journal Detail:
|
Title: International wound journal Volume: 7 ISSN: 1742-481X ISO Abbreviation: Int Wound J Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101230907 Medline TA: Int Wound J Country: England |
Other Details:
|
Languages: eng Pagination: 531-5 Citation Subset: IM |
Copyright Information:
|
© 2010 The Authors. Journal Compilation © 2010 Blackwell Publishing Ltd and Medicalhelplines.com Inc. |
Affiliation:
|
Department of Dermatology, Sisli Etfal Research and Training Hospital, Veysi Paşa sok. Yucekent sit E/16, Altunizade-Istanbul, Turkey. ialtunay@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of recombinant canine interferon-? on granulocyte-macrophage colony-stimulating factor, trans...
Next Document: Microarray and allergenic activity assessment of milk allergens.