Document Detail

Therapy-resistant epilepsy in children: with the view of the long-term outcome.
MedLine Citation:
PMID:  15149307     Owner:  NLM     Status:  MEDLINE    
Of 362 children with therapy-resistant epilepsy, 119 patients had generalized tonic seizures, which were the most common seizure type in patients with generalized epilepsy. The long-term observation of the patients with tonic seizures revealed that their seizures were completely controlled in 27 patients for more than 5 years. The effective antiepileptic drugs were VPA (10 patients), PHT (5), CLB (4), ZNS (2), VPA + PHT (4), ZNS + CLB (1) and VPA + AZA (1). For obtaining improvement of tonic seizures, another strong factor is reducing the number of antiepileptic drugs, such as the average number of drugs, which was 4.7 to 2.4 in these 27 patients.
Tateki Morikawa
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Psychiatry and clinical neurosciences     Volume:  58     ISSN:  1323-1316     ISO Abbreviation:  Psychiatry Clin. Neurosci.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-19     Completed Date:  2004-07-27     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9513551     Medline TA:  Psychiatry Clin Neurosci     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  S7-8     Citation Subset:  IM    
National Epilepsy Center, Shizuoka Medical Institute of Neurological Disorders, Japan.
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MeSH Terms
Anticonvulsants / therapeutic use*
Drug Resistance
Epilepsy / classification,  drug therapy*,  therapy*
Epilepsy, Generalized / drug therapy
Seizures / classification
Treatment Outcome
Reg. No./Substance:

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