| Therapy-resistant depressions: biochemical and pharmacological considerations. | |
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MedLine Citation:
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PMID: 773865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two statements are presented here: 1) antidepressants increase the amount of MA at the central receptors, and 2) antidepressants are effective in some, but quite ineffective in other patients, even if they belong to the same diagnostic category. Three questions result from these statements: 1) Does a central MA deficiency occur in depressive patients? 2) If so, is this disorder present in only a proportion of the patients? 3) If so, can this explain the apparent selectivity of antidepressants in the sense that particularly MA-deficient patients benefit from this type of therapy? A tentative answer is given to these three questions. In depressive patients the cerebral MA turnover can be diminished. These disorders do not occur in all patients but seem to be confined to certain categories of depression. Diminution or non-diminution of the central MA turnover is a (not the) factor which determines whether antidepressant medication will succeed or fail. The theoretical and practical implications of these answers are discussed. |
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Authors:
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H M van Praag |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: International journal of psychiatry in medicine Volume: 6 ISSN: 0091-2174 ISO Abbreviation: Int J Psychiatry Med Publication Date: 1975 |
Date Detail:
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Created Date: 1976-08-02 Completed Date: 1976-08-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0365646 Medline TA: Int J Psychiatry Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 99-111 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjustment Disorders
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metabolism Antidepressive Agents / pharmacology, therapeutic use* Brain / metabolism Depression / cerebrospinal fluid, drug therapy*, metabolism Drug Resistance Homovanillic Acid / cerebrospinal fluid Humans Hydroxyindoleacetic Acid / cerebrospinal fluid Monoamine Oxidase / deficiency, metabolism Norepinephrine / metabolism Probenecid / diagnostic use Receptors, Drug / drug effects Serotonin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Receptors, Drug; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 54-16-0/Hydroxyindoleacetic Acid; 57-66-9/Probenecid; EC 1.4.3.4/Monoamine Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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