Document Detail

Therapy-resistant depressions: biochemical and pharmacological considerations.
MedLine Citation:
PMID:  773865     Owner:  NLM     Status:  MEDLINE    
Two statements are presented here: 1) antidepressants increase the amount of MA at the central receptors, and 2) antidepressants are effective in some, but quite ineffective in other patients, even if they belong to the same diagnostic category. Three questions result from these statements: 1) Does a central MA deficiency occur in depressive patients? 2) If so, is this disorder present in only a proportion of the patients? 3) If so, can this explain the apparent selectivity of antidepressants in the sense that particularly MA-deficient patients benefit from this type of therapy? A tentative answer is given to these three questions. In depressive patients the cerebral MA turnover can be diminished. These disorders do not occur in all patients but seem to be confined to certain categories of depression. Diminution or non-diminution of the central MA turnover is a (not the) factor which determines whether antidepressant medication will succeed or fail. The theoretical and practical implications of these answers are discussed.
H M van Praag
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of psychiatry in medicine     Volume:  6     ISSN:  0091-2174     ISO Abbreviation:  Int J Psychiatry Med     Publication Date:  1975  
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365646     Medline TA:  Int J Psychiatry Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  99-111     Citation Subset:  IM    
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MeSH Terms
Adjustment Disorders / metabolism
Antidepressive Agents / pharmacology,  therapeutic use*
Brain / metabolism
Depression / cerebrospinal fluid,  drug therapy*,  metabolism
Drug Resistance
Homovanillic Acid / cerebrospinal fluid
Hydroxyindoleacetic Acid / cerebrospinal fluid
Monoamine Oxidase / deficiency,  metabolism
Norepinephrine / metabolism
Probenecid / diagnostic use
Receptors, Drug / drug effects
Serotonin / metabolism
Reg. No./Substance:
0/Antidepressive Agents; 0/Receptors, Drug; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 54-16-0/Hydroxyindoleacetic Acid; 57-66-9/Probenecid; EC Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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