Document Detail

Therapy-related acute myeloid leukemia with t(2;11)(q37;q23) after treatment for osteosarcoma.
MedLine Citation:
PMID:  21156246     Owner:  NLM     Status:  MEDLINE    
The survival rate for children with osteosarcoma (OS) has improved dramatically with the introduction of multiagent chemotherapy. As the number of pediatric cancer survivors increases, there is a concern about the development of secondary malignant neoplasms. Secondary acute myeloid leukemia (AML) has been rarely reported after treatment for OS. We describe a 14-year-old boy with OS of the left ileum who developed secondary AML 15 months after completion of treatment. Cytogenetic analysis of the leukemic cells demonstrated deletion 11q23, whereas fluorescence in situ hybridization revealed rearrangement of the MLL gene. Only the addition of the long-distance inverse polymerase chain reaction technique identified the SEPT2 as the MLL fusion partner resulting in t(2;11)(q37;q23) that was reported in a very few secondary AML cases. Because of the cryptic nature of MLL translocations that cannot be detected by conventional cytogenetics or may misinterpreted as deletion, additional molecular techniques are required to identify the precise translocation partner. Because long-distance inverse polymerase chain reaction is not available in most molecular laboratories, the true incidence of t(2;11)(q37;q23) and the involvement of SEPT2 as the MLL translocation partner could be more prevalent in secondary AML.
Bella Bielorai; Claus Meyer; Luba Trakhtenbrot; Hana Golan; Esther Rozner; Ninette Amariglio; Shai Izraeli; Rolf Marschalek; Amos Toren
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  203     ISSN:  1873-4456     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-15     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  288-91     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Department of Pediatric Hematology-Oncology, Safra Children's Hospital, Tel-Hashomer, Israel.
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MeSH Terms
Bone Neoplasms / drug therapy*,  genetics*
Chromosome Deletion
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 2*
Ileum / pathology
In Situ Hybridization, Fluorescence
Leukemia, Myeloid, Acute / genetics*
Middle Aged
Osteosarcoma / drug therapy*,  genetics*
Polymerase Chain Reaction
Translocation, Genetic*

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