Document Detail

Therapy-related acute leukemia with mixed phenotype and t(9;22)(q32;q11.2): a case report and review of the literature.
MedLine Citation:
PMID:  22036054     Owner:  NLM     Status:  Publisher    
Therapy-related acute leukemia showing mixed phenotype is extremely rare. We report a 49-year-old woman who presented with palpable masses in her neck and back. She had received systemic chemotherapy (adriamycin and cisplatin) and radiotherapy for endometrial adenocarcinoma 7 years before. Her peripheral blood and bone marrow showed increased blasts, which coexpressed myeloid (CD13, CD33, and myeloperoxidase) and B-lymphoid antigens (CD19 and CD79a). Cytogenetic analysis showed a karyotype of 46,XX,dup(1)(q21q32),add(5)(q33),t(9;22)(q34;q11.2)[12]/47,idem,+der(22)t(9;22)[8], and BCR/ABL1 rearrangement was detected. Leukemic infiltration was also confirmed in her back mass. After induction chemotherapy with idarubicin, cytarabine, and imatinib, she achieved complete remission. Only 2 cases of therapy-related acute leukemia with mixed phenotype have been reported so far: one with hyperploidy and the other with t(1;21)(p36;q22). To the best of our knowledge, this is the first case of therapy-related acute leukemia with mixed phenotype and t(9;22) as well as extramedullary leukemic infiltrations.
Jin-Hee Cho; Mina Hur; Hee-Won Moon; Yeo-Min Yun; Young Sin Ko; Wan Seop Kim; Mark Hong Lee
Related Documents :
8537504 - Corynebacterium aquaticum septicaemia in a neutropenic patient.
6435254 - Meningococcal meningitis in children: clinical comparison of disease produced by the mi...
14766894 - Treatment of meningitis due to methicillin-resistant staphylococcus epidermidis with li...
16224634 - Varicella pneumonia in immunocompetent adults: report of two cases, with emphasis on hi...
16798704 - Tick-borne encephalitis in eastern france.
3474884 - Ingested retainer: a case report.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-28
Journal Detail:
Title:  Human pathology     Volume:  -     ISSN:  1532-8392     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul 143-729, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic ...
Next Document:  Using the Drinking Expectancy Questionnaire (revised scoring method) in clinical practice.