Document Detail

Therapy insight: drugs for gastrointestinal disorders in pregnant women.
MedLine Citation:
PMID:  16673005     Owner:  NLM     Status:  MEDLINE    
The management and treatment of gastrointestinal ailments in pregnant women requires special attention and expertise, since the safety of the mother, fetus and neonate remains the primary focus. Nausea and vomiting during pregnancy is common, as is symptomatic gastroesophageal reflux disease. Peptic ulcer disease occurs less frequently and with fewer complications. Gastroenterologists and obstetricians should be familiar with safe treatment options for these conditions, because they can profoundly impair the quality of life of pregnant women. During pregnancy, constipation can develop de novo, or chronic constipation can increase in severity. Given the array of therapies for constipation, physicians must apprise themselves of drugs that are safe for both mother and fetus. Management of acute, self-limited diarrhea should focus on supportive therapy, dietary changes and maintenance of hydration. Treatment of chronic diarrhea should be considered in the context of therapy for the underlying disorder. Inflammatory bowel disease and irritable bowel syndrome present a unique therapeutic challenge--to control the disease while minimizing toxicity to the fetus and mother. Initiation and alteration of medical therapy for gastrointestinal disorders during pregnancy must be undertaken after discussion with the patient's obstetrician.
Chandrashekhar Thukral; Jacqueline L Wolf
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature clinical practice. Gastroenterology & hepatology     Volume:  3     ISSN:  1743-4378     ISO Abbreviation:  -     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-04     Completed Date:  2006-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101226510     Medline TA:  Nat Clin Pract Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  256-66     Citation Subset:  IM    
Division of Gastroenterology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA.
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MeSH Terms
Antiemetics / therapeutic use
Constipation / drug therapy
Diarrhea / drug therapy
Doxylamine / therapeutic use
Gastroesophageal Reflux / drug therapy
Gastrointestinal Diseases / drug therapy*
Hyperemesis Gravidarum / drug therapy
Immunologic Factors / therapeutic use
Inflammatory Bowel Diseases / drug therapy
Irritable Bowel Syndrome / drug therapy
Nausea / drug therapy
Peptic Ulcer / drug therapy
Pregnancy Complications / drug therapy*
Reg. No./Substance:
0/Antiemetics; 0/Immunologic Factors; 469-21-6/Doxylamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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