| Therapy of hyperthyroidism in pregnancy and breastfeeding. | |
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MedLine Citation:
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PMID: 21851752 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Uncontrolled hyperthyroidism in pregnancy is associated with an increased risk of perinatal complications. The state of the art discussed here has been derived through a wide MEDLINE search throughout English-language literature by using a combination of words such as hyperthyroidism, propylthiouracil (PTU), methimazole, rituximab, and pregnancy to identify original related works and review articles. Thioamides are the main first-line therapeutic options, whereas beta-blockers and iodine are second-choice drugs; surgery is resorted to only in exceptional cases. Methimazole and PTU reduce the production of thyroid hormones by selectively inhibiting thyroid peroxidase. PTU was once considered to be the first-choice drug in the treatment of gestational hyperthyroidism; however, the United States Food and Drug Administration now recommends it as a second-line thioamide, which should be used solely by women in their first trimester of pregnancy. Thyroidectomy is to be carried out only in pregnant women affected by life-threatening, uncontrollable hyperthyroidism, or in cases with thioamide intolerance. Target Audience: Obstetricians & Gynecologists, Family Physicians Learning Objectives: After completion of this article, the physician should be better able to choose appropriate therapies for hyperthyroidism in pregnant women, assess the risk of possible complications due to maternal hyperthyroidism, and evaluate strategies for patient follow-up. |
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Authors:
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Angela Fumarola; Agnese Di Fiore; Michela Dainelli; Giorgio Grani; Giovanni Carbotta; Anna Calvanese |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Obstetrical & gynecological survey Volume: 66 ISSN: 1533-9866 ISO Abbreviation: Obstet Gynecol Surv Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-08-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401007 Medline TA: Obstet Gynecol Surv Country: United States |
Other Details:
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Languages: eng Pagination: 378-85 Citation Subset: IM |
Affiliation:
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*Research Professor of Endocrinology; †Physician, PhD Student; ‡Physician; §Physician, Resident; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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